Drug molecules with lack of specificity and solubility lead patients to take high doses of the drug to achieve sufficient therapeutic effects. This is a leading cause of adverse drug reactions, particularly for drugs with narrow therapeutic window or cytotoxic chemotherapeutics. To address these problems, there are various functional biocompatible drug carriers available in the market, which ca...

BACKGROUND This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically unde...

Metal nanostructures have attracted great attention in various fields due to their tunable properties through precisely tailored sizes, compositions and structures. Using mesoporous silica (mSiO2) as the inorganic capping agent and encapsulated Pt nanoparticles as the seeds, we developed a robust seeded growth method to prepare uniform bimetallic nanoparticles encapsulated in mesoporous silica ...

in this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by fourier transform infrared spectroscopy, scanning electron microscopy , x-ray diffraction, and ultraviolet-visible. the fourier transform infrared spectroscopy resu...

We report herein a straightforward and label-free approach to prepare luminescent mesoporous silica nanoparticles. We found that calcination at 400 °C can grant mesoporous organosilica nanoparticles with strong fluorescence of great photo- and chemical stability. The luminescence is found to originate from the carbon dots generated from the calcination, rather than the defects in the silica mat...

The goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. Rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. The mesoporous silica nanoparticles were prepared by using tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant). The prepared nanoparti...

curcumin (cur) is a hydrophobic molecule and beneficial antioxidant with known anticancer property. the bioavailability of curcumin is low because of its hydrophobic structure. mesoporous silica nanoparticles (msn) loaded by cur were used as nanocarriers for sustained release of cur in four different media such as simulated gastric,intestinal, colon and body fluids (sgf, sif, scf, and sbf, resp...

In this proof-of-concept study, an agricultural biocide (imidacloprid) was effectively loaded into the mesoporous silica nanoparticles (MSNs) with different pore sizes, morphologies and mesoporous structures for termite control. This resulted in nanoparticles with a large surface area, tunable pore diameter and small particle size, which are ideal carriers for adsorption and controlled release ...

Gold nanoparticles, particularly with the particle size of 2–5 nm, have attracted increasing research attention during the past decades due to their surprisingly high activity in CO and volatile organic compounds (VOCs) oxidation at low temperatures. In particular, CO oxidation below room temperature has been extensively studied on gold nanoparticles supported on several oxides (TiO2, Fe2O3, Ce...

Copper oxide nanoparticles within hollow mesoporous silica spheres were prepared by binding/adsorbing Cu2+ or [Cu(NH3)4(H2O)2]2+ ions on the surface of carbon spheres, followed by formation of a mesoporous silica shell by sol-gel processing and calcination in air. The CuO nanoparticles can subsequently be converted into Cu3N nanoparticles by nitridation with ammonia. The effect of the different...