The paper discusses diverse aspects of the concept epithelial-mesenchymal transition and compares basics this with classical concepts tissue biology. idea was first suggested by Elizabeth Hay (1927–2007) in 1968 based on analysis tridermogenesis development growth avian embryo. In late 80 s – early 90 twentieth century, epithelial–mesenchymal won supporters-pathomorphologists our country who ap...

MUC1 is a transmembrane glycoprotein, apically expressed in most epithelial cells, used in the differential diagnosis of carcinomas and for discrimination of tumors of non-epithelial origin showing epithelioid features. Little attention has been paid so far though, on its possible significance in embryonic tissues. A preliminary study from our group revealed MUC1 expression in the cap mesenchym...

Calcineurin inhibitors cyclosporine and tacrolimus are effective immunosuppressants, but both substances have the same intrinsic nephrotoxic potential that adversely affects allograft survival in renal transplant patients and causes end-stage renal disease in other solid organ or bone marrow transplant recipients. Endothelial cells are the first biological interface between drugs and the kidney...

Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition. Additionally, cellular stress is accompanied by endoplasmic reticulum-stress which induces an unfolded protein response. It is unknown if epithelial-mesenchymal transition and endoplasmic reticulum-stress are ...

Tumor necrosis factor-alpha is a critical pro-inflammatory cytokine produced by macrophages and was once considered an anti-tumor agent. However, a low dose of tumor necrosis factor-alpha can cause epithelial mesenchymal transition, angiogenesis and metastasis. NF-κΒ contributes to epithelial mesenchymal transition induced by tumor necrosis factor-alpha. Kanglaite, an extract from the Coix lacr...

Pathology and NYU Cancer Institute, NYU Langone Medical Center, New York, New York; OSI Pharmaceuticals, Farmingdale, New York; Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York; and Department of Surgery, University of Melbourne, St. Vincent’s Hospi...

The skin is a composite structure composed of a superficial epidermis and an underlying dermis. Wounding of this structure with resultant functional and anatomical disintegration leads to a cascade of events directed at the restoration of these features. However, maintenance of anatomical integrity has a higher priority from the standpoint of preservation of homeostatic equilibrium. The uncoupl...

OBJECTIVE Emergency medical technicians (EMTs) in Iran enter the workplace after a short academic education. Their workplace has high emotional fluctuations and imposes high pressure. The aim of this study was to assess the challenges faced by EMT graduates in Iran. DESIGN This applied study was conducted using qualitative content analysis. Twelve paramedics and graduates with 2 to 3 years of...