BACKGROUND Abnormal uterine bleeding is often investigated in clinical studies and critical to identify during gynecological consultation. The current standard for quantification of menstrual blood loss is the alkaline-hematin-method. However, this method is expensive and inconvenient for patients. Bleeding diaries, although widely used, provide only qualitative information on menstrual blood l...

Normal physiological variables, such as age and gender, contribute to alterations in circulating microRNA (miRNA) expression levels. The changes in the female body during the menstrual cycle can also be reflected in plasma miRNA expression levels. Therefore, this study aimed to determine the plasma miRNA profile of healthy women during the menstrual cycle and to assess which circulating miRNAs ...

We are in the beginning of the era of regenerative medicine and many researchers are testing adult stem cells to be used for tissue repair and regeneration in the human body. Many adult stem cells have been discovered since the late 1990's with more recently a novel adult stem cell described in menstrual blood. The menstrual blood is derived from shedding of the endometrial lining, specifically...

Angiogenesis is the process of formation of new blood vessels from the blood vessels that already exist. This process is an essential factor in each menstrual cycle. Neovascularisation or formation of new blood vessel is the process occurs often in endometrium during every menstrual cycle. Abnormal angiogenesis may have a profound effect on the pathogenesis of endometrial carcinoma and abnormal...

multiple sclerosis is a chronic inflammatory disease of central nervous system.women are more susceptible to this disease. one of the obvious clinical complaints in women with multiple sclerosis specially treated with beta interferones is menstrual cycle irregularity. the aim of this study was to determine the prevalence of menstrual irregularities and probable changes in blood levels of relate...

BACKGROUND It has been previously suggested that angiogenesis occurs during the menstrual cycle. Moreover, a rise in uterine blood flow is largely maintained by vasodilatation and substantial increases in angiogenesis. It is known that estradiol (E2) and progesterone (P4) are involved in angiogenesis. Recently, endothelial progenitor cells (EPCs) were found to be involved in neovascularization;...

Objective. To find a convenient and efficient way to isolate MSCs from human menstrual blood and to investigate their biological characteristics, proliferative capacity, and secretion levels. Methods. MSCs were isolated from menstrual blood of 3 healthy women using adherence. Cell immunological phenotype was examined by flow cytometry; the adipogenic, osteogenic, and chondrogenic differentiatio...

Objective: To examine the effects of menstrual cycle on exercise-induced inflammation, we investigated exercise-induced changes in circulating cytokines and leukocyte responses during different phases of the menstrual cycle. Methods: Ten healthy sedentary females (20.5 ± 0.7 years) performed 60 min of cycling at 75% of their individual anaerobic threshold (AT) during the three different phases ...