statement of the problem melatonin has powerful antioxidant effects, has an immunomodulatory role, stimulates the synthesis of type i collagen fibers, and promotes bone formation. melatonin is also secreted in the saliva, although its role in the mouth is not known well purpose the aim of this study was to examine the correlation between salivary melatonin level and periodontal diseases materia...

objective(s): there are few reports have demonstrated the effect of a change-in-light experience on the structure and function of hippocampus. a change-in-light experience also affects the circadian pattern of melatonin secretion. this study aimed to investigate developmental effect of exogenous melatonin on synaptic plasticity of hippocampus of light deprived rats. materials and methods: the e...

this study investigates the effects of melatonin on the sperm quality and testis weight after the combination of swimming exercise and nandrolone decanoate (deca). two groups of male wistar rats were treated for eight weeks as follows; group a consist of co (control), sham, n (deca), s (swimming) and ns (deca plus swimming); and group b: sham m (sham melatonin), m (melatonin), mn (melatonin plu...

The hormone melatonin phase shifts circadian rhythms generated by the mammalian biological clock, the suprachiasmatic nucleus (SCN) of the hypothalamus, through activation of G protein-coupled MT2 melatonin receptors. This study demonstrated that pretreatment with physiological concentrations of melatonin (30-300 pM or 7-70 pg/mL) decreased the number of hMT2 melatonin receptors heterologously ...

We studied the subcellular levels of melatonin in cerebral cortex and liver of rats under several conditions. The results show that melatonin levels in the cell membrane, cytosol, nucleus, and mitochondrion vary over a 24-hr cycle, although these variations do not exhibit circadian rhythms. The cell membrane has the highest concentration of melatonin followed by mitochondria, nucleus, and cytos...

objective(s):transplantation quality improvement and reduction of cellular damage are important goals that are now considered by researchers. melatonin is secreted from the pineal gland and some organs such as testes. according to beneficial effects of melatonin (such as its antioxidant and antiapoptotic properties), researchers have proposed that the use of melatonin may improve transplantatio...

objective: nutrients and antioxidants in the medium of immature oocyte have a profound effect on maturation, fertilization and development of resulting embryos. in this study the effects of melatonin as an antioxidant agent on maturation, glutathione level and expression of high mobility group box-1 (hmgb1) gene were evaluated in immature oocytes of mice stained with brilliant cresyl blue (bcb)...

multiple sclerosis is an autoimmune disease of the central nervous system which is accompanied by demyelinating the neurons. the imbalance between the t cell effectors and t cell regulators is thought to have a role in the pathogenesis of the disease. melatonin is a hormone that is secreted by pineal gland which has an important role in circadian rhythm and immune-modulatory effects. melatonin ...

This study investigated B16F10 melanoma cell death induced by melatonin combined with endoplasmic reticulum (ER) stress through the PI3K/Akt/mTOR pathway. Cell viability was significantly decreased after treatment with melatonin combined with ER stress from thapsigargin or tunicamycin compared to no treatment or treatment with melatonin only. Combined melatonin and ER stress also significantly ...