Hydroxycarbamide is used in the treatment of essential thrombocytosis and other myeloproliferative disorders. We report the case of a 63-year-old woman with essential thrombocytosis who had melanonychia after the long-term use of the hydroxycarbamide with a dose of 1000 mg/day. Two years after the initiation of the hydroxycarbamide, our patient had pain on her toes and melanonychia on her nails...

Laugier-Hunziker syndrome is an acquired macular hyperpigmentation of the oral and genital mucosa, often associated with longitudinal melanonychia. We report a case of longitudinal melanonychia on fingernails and toenails, hutchinson's signal and lenticular pigmentation of her lips and oral mucosa. Histopathological analysis is typical and had a broad differential diagnosis. This is a rare and ...

this is a picture presentation of myeloproliferative disorder developing to longitudinal melanonychia as a side effect of hydroxyurea. keywords: melanonychia, hydroxyurea, side effect.

Figure 1. Melanonychia of the small finger of the left hand with biopsy site from trephination. Biopsy was inconclusive , and more invasive biopsy was warranted. Figure 2. Complete nail plate removal for biopsy with insertion of sterile silicone sheeting in nail fold to prevent synechiae.

__________________________________________________________________________________ Abstract The development of melanonychia is one of the adverse effects of the antiretroviral drug zidovudine. We evaluated 19 adult patients treated with zidovudine and showing nail lines, an unusual side effect sometimes reported. Liver, kidney and pancreas function, as the metabolic function of these patients w...

Onychomatricoma is a rare tumour of the nail matrix with peculiar clinical and histological features and electron microscopic findings. We report on 5 cases with appearances which were misleading. Three presented as longitudinal melanonychia, a previously unreported observation. One case had the appearance of a cutaneous horn. In 3 of the 5 cases the tumour was associated with an onychomycosis ...

KEY LEARNING POINTS MS is defined as a single or multiple black/brown pigmentation bands arranged lengthwise along the nail unit. Physiological MS is more commonly seen in darker phototype individuals and is quite unusual in fair-skinned ethnic groups. MS is the result of increased melanin production by nail matrix melanocytes, which produces a visible pigmentation band in the nail plate. Disti...