We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean c...

We have described a case of chronic arsenic intoxication associated with pancytopenia and megaloblastic erythropoiesis. The patient had the typical laboratory manifestations of effective erythorpoiesis due to a megaloblastic process, including macroovalocytes, mild pancytopenia, low reticulocyte index, increased marrow cellularity with erythroid hyperplasia, and morphologic evidence of megalobl...

Megaloblastic anemia is categorized by distinguished hematopoietic cell morphology, unproductive hematopoiesis, induced by folic acid and/or vitamin B12 deficiency [1]. Ineffective DNA synthesis in hematopoietic progenitor cells or myelodysplastic syndrome leading to congenital disorders is commonly responsible for the megaloblastic anemia. In western populations, cobalamin (vitamin B12) defici...

The erythrocyte membrane protein pattern of patients with megaloblastic anemia was determined by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. In severe megaloblastic anemia, secondary either to folic acid or vitamin B12 deficiency, the erythrocyte membrane protein pattern was grossly abnormal, lacking bands 1, 2 (spectrin), and 3 and having several diffuse, faster migrating ban...

We present an eight-year-old boy who initially presented to us with megaloblastic anemia and subsequently developed dislocation of lens. The child had a positive sodium nitroprusside test and homocystinuria. He was diagnosed to have homocystinuria type 1. His anemia improved on oral pyridoxine and folic acid therapy. Homocystinuria should be remembered as a cause of megaloblastic anemia.

We prospectively studied 478 patients with megaloblastic anemia living in Tunisia. Overall, 98% of patients had vitamin B12 deficiency. Pernicious anemia accounted for most of these cases, and median age at presentation was 45 years. Megaloblastic anemia occurred in 19 subjects under 15 years of age, and of these, nine had the Immerslund-Graesbeck syndrome.

Psoriasis is known to be one of the skin diseases which can cause folate deficiency (1-3). However, psoriasis alone rarely produces folate deficiency severe enough to be associated with megaloblastic anemia (1-3). Recently, methotrexate has been widely used as an effective therapy for patients with severe psoriasis who are resistant to conventional agents (4), but such therapy increases the ris...

The present study describes a case of an elderly patient that was hospitalized secondary to hypotension and delirium. Physical examination at admission revealed bilateral positive Babinski's sign. Laboratory examination revealed severe anemia. Bone marrow examination showed megaloblastic changes of the granulocyte and erythroid series, as well as other dyshaematopoiesis. The conditions of the p...

W e report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXl is rapidly measured as part of an automated complete blood count (Technicon H.1, Technicon Instruments Corp, Tarrytown NY). W e describe the range of MPXl levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean...