Toxic megacolon complicating inflammatory or infective colitis carries a high morbidity and mortality and surgical intervention is necessary in up to 80% of cases. Perforation complicates toxic megacolon in about 35% of cases. After perforation, the death rate nears 50%. Gaseous distension of the bowel causes considerable discomfort to the patient and increases transmural pressure. The latter i...

I do not intend to give an account of the changing philosophies concerning the aetiology and treatment of the disease which followed upon Hirschsprung's (1888) first presentation of it as an entity in 1886. It required about 60 years of vague or wrong ideas to find the key to our present knowledge. That happened when our attention was diverted from the characteristic megacolon and was focused o...

I do not intend to give an account of the changing philosophies concerning the aetiology and treatment of the disease which followed upon Hirschsprung's (1888) first presentation of it as an entity in 1886. It required about 60 years of vague or wrong ideas to find the key to our present knowledge. That happened when our attention was diverted from the characteristic megacolon and was focused o...

Introduction: Optimal management of toxic megacolon as a consequence Cl. difficile colitis is still matter controversy, well timing available therapeutic modalities. In this article we report case severe C. associated with in pregnant patient Covid 19, who was successfully treated conservatively. Case Report: A 33-years old woman contracted SARS-CoV-2 the 32nd week pregnancy. She admitted to re...

BACKGROUND AND AIMS Gastrointestinal disorders is one of the clinical manifestations of chronic Chagas' disease. The pathogenesis seems to be associated with autonomic dysfunction. Here, we consider the muscarinic cholinoceptor mediated alteration in distal colon function in chagasic megacolon. PATIENTS Patients were divided into four groups: group I, chronic chagasic patients with megacolon;...

We studied the survival and gene expression of glial cell line-derived neurotrophic factor (GDNF) and GDNF receptor α-1 (GFRα-1) double-genetically modified rat bone marrow mesenchymal stem cells (BMSCs) transplanted into the intestinal walls of the rat models with congenital megacolon and determine the feasibility of treatment by transplantation of double-genetically modified rat BMSCs. The ra...

The classic piebald mutation in the endothelin receptor type B (Ednrb) gene was found on rolling Nagoya genetic background (PROD-s/s) mice with white coat spotting. To examine whether genetic background influenced the phenotype in the piebald mutant mice, we generated a congenic strain (B6.PROD-s/s), produced by repeated backcrosses to the C57BL/6J (B6) strain. Although B6.PROD-s/s mice showed ...

I do not intend to give an account of the changing philosophies concerning the aetiology and treatment of the disease which followed upon Hirschsprung's (1888) first presentation of it as an entity in 1886. It required about 60 years of vague or wrong ideas to find the key to our present knowledge. That happened when our attention was diverted from the characteristic megacolon and was focused o...