Recently, as urbanization and industrialization progresses, we have witnessed an increasing number of very large scale development projects (termed mega projects in this paper) all around the world, especially in developing and emerging countries such as Brazil, Russia, India, and China (BRICs). At the same time, issues with mega project decision-making are drawing special attention from invest...

Vertebrate claudin proteins are integral components of tight junctions, which function as paracellular diffusion barriers in epithelia. We identified Megatrachea (Mega), a Drosophila transmembrane protein homologous to claudins, and show that it acts in septate junctions, the corresponding structure of invertebrates. Our analysis revealed that Mega has transepithelial barrier function similar t...

Mega cisterna magna is a part of "Dandy-Walker Complex" and it is characterized by the enlargement of the cisterna magna, morphologically intact vermis and cerebellar hemispheres. We report a case of manic attack in a 23-year-old man with mega cisterna magna. The patient was treated with quetiapine 1,000 mg/day and sodium valproate 1,500 mg/day and the symptoms were ameliorated within 2.5 month...

We present the latest version of the Molecular Evolutionary Genetics Analysis (Mega) software, which contains many sophisticated methods and tools for phylogenomics and phylomedicine. In this major upgrade, Mega has been optimized for use on 64-bit computing systems for analyzing larger datasets. Researchers can now explore and analyze tens of thousands of sequences in Mega The new version also...

Introduction. One commonly used method for in-vivo magnetic resonance spectroscopy (MRS) detection of γ-aminobutyric acid (GABA) is the MEGA-PRESS technique [1], which enables direct observation of the GABA resonance at 3.02 ppm. Unfortunately, direct quantification of GABA using MEGA-PRESS is complicated by co-editing of macromolecule (MM) signals, which also resonate at 3.02 ppm [2]. Two meth...

background: in conventional radiation therapy, regarding normal tissue tolerance, the treatment of bulk tumors is one of the remaining challenges. grid radiation therapy (grt) is a technique to deliver high doses, approximately 15 – 20 gy per fraction, to several small volumes located in a large radiation field. this can be performed using a grid block. the current work has concentrated on the ...

Efflux-mediated macrolide resistance due to mef(E) and mel, carried by the mega element, is common in Streptococcus pneumoniae, for which it was originally characterized, but it is rare in Streptococcus pyogenes In S. pyogenes, mega was previously found to be enclosed in Tn2009, a composite genetic element of the Tn916 family containing tet(M) and conferring erythromycin and tetracycline resist...

The dilatations that occur in the body are classified according to different systems: (1) biliary: mega-gallbladder, mega-common bile duct; (2) cardiovascular: cardiomegaly; (3) urinary: megapelvis, megaureter, megabladder; (4) respiratory: bronchiectasis, megabronchus; (5) megapharynx (?); (6) megaesophagus; (7) megastomach; (8) achalasia of the pylorus or hypertrophic pyloric stenosis; (9) me...