Among the four different types of thyroid cancer, treatment of medullary thyroid carcinoma poses a major challenge because of its propensity of early metastasis. To further investigate the molecular mechanisms of medullary thyroid carcinoma and discover candidates for targeted therapies, we developed a new mouse model of medullary thyroid carcinoma based on our CGRPCreER mouse line. This system...

The salient features of 15 cases of carcinoma of the thyroid and phaeochromocytoma taken from the literature and two personal cases are reviewed. The significant points noted are the frequency with which the adrenal tumours were bilateral, the frequency with which a family history of phaeochromocytoma (six cases) and thyroid carcinoma (four cases) was present, and the frequency with which the t...

Twenty-one patients with medullary thyroid carcinoma were studied prospectively with Tc-99m (V) DMSA after surgery. Pentavalent DMSA scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. Finally, seven patients with surgical or other imaging documentation were selected for this paper. Most of these patients were asymptomatic. Six patients had hypercalcitonemia ...

SYNOPSIS The salient features of 15 cases of carcinoma of the thyroid and phaeochromocytoma taken from the literature and two personal cases are reviewed. The significant points noted are the frequency with which the adrenal tumours were bilateral, the frequency with which a family history ofphaeochromocytoma (six cases) and thyroid carcinoma (four cases) was present, and the frequency with whi...

Medullary thyroid carcinoma can arise as a component of multiple endocrine neoplasia (MEN) syndrome which includes adrenal pheochromocytoma. Familial medullary thyroid carcinoma with no association of other components of MEN syndrome is also reported. Epinephrine and norepinephrine excreted in 24 hour urine and/or randomly voided urine were measured for screening of pheochromocytoma in patients...

Misfolding and aggregation of amyloid peptides are critical pathological events in numerous protein misfolding diseases (PMDs), such as Alzheimer’s disease (AD), type II diabetes (T2D), medullary thyroid carcinoma (MTC)....

INTRODUCTION Papillary thyroid carcinoma and medullary thyroid carcinoma are two different thyroid neoplasia. The simultaneous occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma as a collison tumor with metastases from both lesions in the regional lymph nodes is a rare phenomenon. CASE PRESENTATION A 32-year-old Iranian man presented with a fixed anterior neck mass. Ult...

With fewer than 40 cases described in the otolaryngology literature, mixed medullary papillary thyroid carcinoma represents a rare but phenotypically distinct tumor. While isolated medullary carcinoma may be admixed with normal follicular structures, true mixed carcinoma displays morphological and immunological characteristics of medullary and papillary carcinoma within a single lesion. We repo...

we report an unusual case of a young male with cerebellar hemangioblastoma treated previously for medullary carcinoma of thyroid, whose pet/ct scans revealed a constellation of findings that suggested the rare von hippel lindau syndrome. the diagnosis was clinched by confirming the findings on whole body contrast enhanced computed tomography (cect) and contrast enhanced magnetic resonance imagi...