BACKGROUND/AIMS Three missense mutations clustered on the carboxyl-terminal portion of the MEFV gene (M680I, M694V, and V726A) have been observed in over 80% of affected alleles in several ethnic groups of familial Mediterranean fever patients. Several immunologic abnormalities were found both in cellular and humoral components in Mediterranean fever patients. Those observations have pointed th...

background familial mediterranean fever (fmf) is an autosomal recessive disorder characterized by sporadic, paroxysmal attacks of fever and serosal inflammation. although the disease usually begins before the age of 20 years, we aimed to evaluate the demogra­phy, clinical features and treatment outcome of familial mediter­ranean fever in iranian adult patients above 20 years old. methods in thi...

conclusions this case showed the effect of additional anakinra on children with fmf who were colchicine resistant. case presentation herein was reported a colchicine non-responsive patient with accurate diagnosis and early treatment of fmf. she had presented with recurrent and persistent acute abdominal pain attacks and several abdominal surgeries. addition of recombinant interleukin-1 receptor...

Familial Mediterranean Fever, the most common autoinflammatory disease, is inherited in an autosomal recessive pattern. During the recent years, a new phenotype has been described concerning heterozygous carriers of Mediterranean Fever (MEFV) mutations that express typical clinical features of Familial Mediterranean Fever (FMF). This new pattern of genotype-phenotype correlation is called “FMF-...

. Conca W, Ghatasheh G, Al-Salam S, Neidl Van Gorkom K. The medical odyssey of a boy with arthritis of familial Mediterranean fever. Int J Rheum Dis. 2012;15:37--9. . Lidar M, Kedem R, Mor A, Levartovsky D, Langevitz P, Livneh A. Arthritis as the sole episodic manifestation of familial Mediterranean fever. J Rheumatol. 2005;32:859--62. . Majeed HA, Rawashdeh M. The clinical patterns of arthriti...

Is familial Mediterranean fever a possible cofactor for Budd-Chiari syndrome? J Pediatr Gastr Nutr 2009;49:481–4. 9 Aksu G, Ozturk C, Kavakli K, Genel F, Kutukculer N. Hypercoagulability: interaction between inflammation and coagulation in familial Mediterranean fever. Clin Rheumatol 2007;26:366–70. 10 Demirel A, Celkan T, Kasapcopur O et al. Is familial Mediterranean fever a thrombotic disease...

BACKGROUND/AIM The aim of this study was to investigate the relationship between familial Mediterranean fever and female sexual dysfunction and premenstrual syndrome. MATERIALS AND METHODS This study included 36 patients with familial Mediterranean fever and 33 healthy volunteers. Familial Mediterranean fever was diagnosed according to the Tel Hashomer criteria and familial Mediterranean feve...

Background. Eosinophilic esophagitis is an inflammatory condition where there is a dense infiltration of eosinophils typically exceeding fifteen cells per high power field. Familial Mediterranean fever is an autosomal recessive disorder characterized by brief, acute, and self-limited episodes of fever and polyserositis that recur at irregular intervals. Case Presentation. A three-year-and-nine-...

Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease characterized by recurrent fever with serosal inflammation. We experienced a 53-year-old male who had been suffering from periodic attacks with slight fever and myalgia which were mainly triggered by cold exposure in winter. Although his clinical course did not satisfy the criteria for familial Mediterranean fever, heteroz...

Familial Mediterranean fever is a multisystem disorder, usually seen in subjects of Mediterranean and Middle Eastern origin, characterized by recurrent bouts of fever and pain due to inflammation of the peritoneum, synovia, or pleura. In this article we report a case of Familial Mediterranean fever with recurrent abdominal pain and hyperbilirubinemia, review the literature and discuss whether t...