Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...

Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...

Based on QSAR studies two new DHP calcium-channel blockers, mebudipine and dibudipine, were synthesis and evaluated for their pharmacological activity in various tissues. These studies showed that, these compounds, with potency comparable or greater than that of nifedipine could relax the smooth muscles of various vascular tissues. Electrophysiological study showed that they antagonized calcium...