We have suggested, several years ago, an association between the measles virus and classical Hodgkin lymphoma. However, this relationship was not accepted by the isolated research groups which dealt with the issue. In this short commentary, we recall the traits of the virus which were suggestive of a familiarity with Hodgkin lymphoma. We mention, in addition, older articles which highlight thes...

OBJECTIVE To identify measles virus genotypes in three cases of travelers suspected of measles infection. METHODS Samples (blood and urine) were collected for serology, virus isolation, and genotyping. Sera were analyzed for IgM antibodies against measles virus and rubella virus by enzyme-linked immunosorbent assay (ELISA) (Siemens - Marburg, Germany). Clinical samples (lymphocytes and urine)...

The global increase in measles vaccination has resulted in a significant reduction of measles mortality. The standard route of administration for the live-attenuated measles virus (MV) vaccine is subcutaneous injection, although alternative needle-free routes, including aerosol delivery, are under investigation. In vitro, attenuated MV has a much wider tropism than clinical isolates, as it can ...

Measles virus (MV) has been under control in Brazil because of the high coverage rates of immunization. Emphasized by the measles control global program at the Pan American Health Organization, with the use of several strategies of vaccination programs to reduce the number of circulating chains of transmission of the virus, these programs have successfully decreased the incidence of measles on ...

Among vaccine-preventable diseases, measles is the preeminent killer of children worldwide. Infection with measles virus (MV) is associated with prolonged suppression of cell-mediated immune responses, a phenomenon that is thought to underlie the susceptibility to secondary infections that accounts for most measles-related mortality. Interleukin (IL)-12 is critical for the orchestration of cell...

Measles remains a significant cause of childhood morbidity and mortality. Hallmark of the disease is a generalized immune suppression that can last for several weeks to months after resolution of measles virus (MV) infection [1–3], resulting in increased susceptibility to opportunistic infections [4–7]. At the same time, measles is associated with immune activation and induces strong MV-specifi...

A variety of vaccine platforms are under study for development of new vaccines for measles. Problems with past measles vaccines are incompletely understood and underscore the need to understand the types of immune responses induced by different types of vaccines. Detailed immune response evaluation is most easily performed in mice. Although mice are not susceptible to infection with wild type o...

Measles has a host range restricted to humans and monkeys in captivity. Fresh measles virus (MV) isolates replicate readily in several human and simian B-cell lines but need a period of adaptation to other types of cells. The identification of CD46 and CD150 (SLAM) as cellular receptors for MV has helped to clarify certain aspects of the immunobiology of MV infections. We have examined the prop...

Although treatment of medulloblastoma has improved, at least 30% of patients with this tumor die of progressive disease. Unfortunately, many of the children who survive suffer long-term treatment-related morbidity. Previous studies have demonstrated the efficacy of using oncolytic viruses to eradicate brain tumors. The objective of this study was to test the efficacy of measles virus in treatin...