he only confirmed mechanism for protein-mediated membrane fusion involves the formation of helix bundles, in which helices attached to two membranes pack against one another to draw together the membranes. In the final fused state, six-helix bundles are formed by HIV Env and paramyxovirus F proteins, members of the class I group of viral fusion proteins. Although the class I founding member, in...

I shall devote the body of this paper to a description of experiments with rats. But I shall also attempt in a few words at the close to indicate the significance of these findings on rats for the clinical behavior of men. Most of the rat investigations, which I shall report, were carried out in the Berkeley laboratory. But I shall also include, occasionally, accounts of the behavior of non-Ber...

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Attention is drawn to several comparisons of the ARC feeding system with other systems. Recent Australian adaptations of ME standards for drought feeding of sheep and for cattle feeding are described. There is a need to adapt any feeding standards to the biology of the pastoral system. It is concluded that the Australia-wide adoption of ME based feeding standards would be helpful in promoting a...

Let me answer this question unequivocally. It depends. Figured out I’m a consultant yet? Actually, let me explain. It does depend. It depends on what you think patterns are. Many people have a misunderstanding of patterns, and for those people, patterns can be harmful. However, when people get past their early understanding of patterns and come to comprehend them in a richer way, patterns canno...

This paper proposes a model of meta-reflection and in-depth analysis of the knowledge creation process (KCP). The authors focus on observation of the KCP in research on creative design. The new method of meta-reflection is applied both to reflection on ‘research about design creativity’ and object of research—‘design creativity’. One result of the applied method of meta-reflection was that the ...

The therapeutic effect of ME1228, a new parenteral cephalosporin, was compared with that of broad-spectrum cephems in normal and neutropenic mice infected with various species of bacteria. The results showed that ME1228 was more active than were the other cephems against infections with various pathogens.