Crypt foci with absent or scant mucous production (mucin-depleted foci, MDF) were recently described by our group in the colon of azoxymethane (AOM)-treated rats. Since MDF are dysplastic and easy to quantify, we think that MDF are pre-neoplastic lesions that could be used as biomarkers for carcinogenesis. To test this hypothesis, we studied MDF in azoxymethane (AOM)-initiated rats treated with...

An accurate and efficient algorithm, closely related to the level set method, is presented for the simulation of Mullins’s model of grain growth with arbitrarily prescribed surface energies. The implicit representation of interfaces allows for seamless transitions through topological changes. Well-resolved large-scale simulations are presented, beginning with over 650,000 grains in two dimensio...

As opposed to “big data” as a buzz word, we attempt to find a new pattern or structure generated by selforganization in the flow of the massive data. We call this approach Massive Data Flows (MDF). Rather than making use of big data, we are interested in the new phenomena and theory that allows us to deal with the data without losing the autonomy, complexity, dynamics and structure that the dat...

OBJECTIVE To compare cycle outcomes among normal-responding patients <or=30 years old receiving microdose follicular flare (MDF) and long-luteal agonist (LL). DESIGN Retrospective cohort study. SETTING Military-based assisted reproductive technology (ART) center. PATIENT(S) First autologous ART cycles among 499 women <or=30 years old from January 1999 to December 2005. INTERVENTION(S) A...

SARNA, S. K., AND E. E. DANIEL. Electrical stimulation of gastric electrical control activity. Am. J. Physiol. 225(l): 125-131. 1973.Gastric electrical control activity in anesthetized dogs was stimulated by voltage pulses of 100 msec duration and lto 25-v amplitude. The gastric control waves could be entrained from any site in the electrically active region on the anterior and posterior sides....

Macrophage deactivation factor (MDF) in P815 tumor cell-conditioned medium was assayed by its suppression of the ability of activated mouse peritoneal macrophages to release hydrogen peroxide. MDF displayed properties of a soluble protein(s) associated with both low (8-25,000) and high (greater than 450,000) Mr fractions. MDF was purified 6,140-fold by a seven-step procedure: extraction with ac...

BACKGROUND Alcoholic hepatitis is associated with altered hepatic artery hemodynamics. Maddrey's discriminant function (MDF) can identify patients with poor prognosis (DF >32). We studied hepatic artery hemodynamic parameters of hepatic artery diameter (HAD), resistive index (RI) and pulsatility index (PI) in severe acute alcoholic hepatitis (SAAH) and for the presence of correlation of paramet...

An improved mass defect filter (MDF) method employing both drug and core structure filter templates was applied to the processing of high resolution LC/MS data for the detection and structural characterization of oxidative metabolites with mass defects similar to or significantly different from those of the parent drugs. The effectiveness of this approach was investigated using nefazodone as a ...

Mucin depleted foci (MDF) are precancerous lesions of the colon in carcinogen-treated rodents and humans at high risk. Since MDF show signs of inflammation we hypothesized that the defective mucous production would expose them to the risk of being penetrated by intestinal bacteria, which can be sensed by Toll-like receptors (Tlrs) and activate inflammatory pathways. To verify this hypothesis we...

An improved mass defect filter (MDF) method employing both drug and core structure filter templates was applied to the processing of high resolution liquid chromatography/mass spectrometry (LC/MS) data for the detection and structural characterization of oxidative metabolites with mass defects similar to or significantly different from those of the parent drugs. The effectiveness of this approa...