Evaluation of drug-drug interaction (DDI) involving circulating inhibitory metabolites of perpetrator drugs has recently drawn more attention from regulatory agencies and pharmaceutical companies. Here, using amiodarone (AMIO) as an example, we demonstrate the use of physiologically based pharmacokinetic (PBPK) modeling to assess how a potential inhibitory metabolite can contribute to clinicall...

The 3,4-methylenedioxy-methamphetamine (MDMA)-related designer drug 3,4-methylenedioxyethylamphetamine (MDEA, Eve) is a chiral compound that is mainly metabolized by N-deethylation and demethylenation during phase I metabolism. The involvement of several cytochrome P450 (P450) isozymes in these metabolic steps has been demonstrated by inhibition assays using human liver microsomes. However, a c...

1. The ability of N-ethyl (MDEA) and N-butyl (MDBA) analogues of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') to induce acute behavioural changes and increases in body temperature, and to cause serotonergic neurotoxicity, was assessed in young adult male Wistar rats. The in vitro ability of MDMA analogues to evoke presynaptic monoamine release from crude rat forebrain synaptosomal prepar...

In recent years, many multimedia and image encryption techniques based on chaotic maps have been proposed. In this paper, we propose a novel multimedia data encryption technique called MDEA (Multimedia Data Encryption Algorithm). Proposed encryption scheme is based on two digital chaotic maps, which in turn are used to generate two different chaotic sequences. Detail description of the proposed...

In the present study, results from three different CO2 capture experimental scales (laboratory, pilot unit, and a larger pilot unit), using aqueous amine solutions of methyldiethanolamine (MDEA) 20 wt %, are compared in terms of loading capacity. All three tested scales produced results regarding CO2 absorption using MDEA aqueous solutions, which were largely in accordance with the theoretical ...

first described by Gusserow in 1870 as a well differentiated adenocarcinoma in which most of the glands are impossible to be distinguished from the normal endocervical mucosa, although the MDA invades deep into the cervical stroma. At first, MDA was restricted to the mucinous type, but the definition of MDA has been expanded to other cell types, including the endometrioid, clear cell and nonspe...

Gas sweetening, the removal of acid gases (H2S and CO2) by absorption in aqueous alkanolamine solutions, is an important gas treatment operation. Methyldiethanolamine (MDEA) is widely employed for gas sweetening, because of its high absorption capacity and flexibility to meet process requirements. For process simulation or design, realistic predictions of acid gas solubilities in MDEA solutions...

In the present study the apphcatlon of a hquld membrane for selectlve removal of HsS from gases also contannng COz was mvestlgated The hquld membrane was filled with pure methyl-di-ethanol-amme (MDEA) A theoretical model was developed to descrrbe (a) the chemical equlllbnum between the dissolved gas and MDEA m the membrane and (b) the physical equlhbnum between the solute (CO, and HsS) m the ga...

The 3,4-methylenedioxy-methamphetamine (MDMA)-related designer drug 3,4methylenedioxyethylamphetamine (MDEA, Eve) is a chiral compound which is mainly metabolized by N-deethylation and demethylenation during phase I metabolism. The involvement of several cytochrome P450 (P450) isozymes in these metabolic steps has been demonstrated by inhibition assays using human liver microsomes. However, a c...