نتایج جستجو برای: mda
تعداد نتایج: 20691 فیلتر نتایج به سال:
background: melatonin is a free radical scavenger. it has also antioxidant effects through its stimulatory actions on antioxidant system. objective: we conducted this study to examine the effect of different oral doses of melatonin on liver tissue. methods: we used 42 rats—6 rats in each group. group i served as the control group; group ii rats were pretreated with only melatonin; group iii was...
Although drug resistance is often observed in metastatic recurrence of breast cancer, little is known about the intrinsic drug resistance in such metastases. In the present study, we found, for the first time, that MDA-MB-231BR, a brain metastatic variant of a human breast cancer cell line, was refractory to treatment with 5-fluorouracil (5-FU) even without chronic drug exposure, compared to it...
Oxidation-associated malondialdehyde (MDA) modification of proteins can generate immunogenic neo-epitopes that are recognized by autoantibodies. In health, IgM antibodies to MDA-adducts are part of the natural antibody pool, while elevated levels of IgG anti-MDA antibodies are associated with inflammatory and autoimmune conditions. Yet, in human autoimmune disease IgG anti-MDA responses have no...
High Density Lipoprotein (HDL) plays a protective role in abdominal aortic aneurysm (AAA); however, recent findings suggest that oxidative modifications could lead to dysfunctional HDL AAA. This study aimed at testing the effect of oxidized on lesions and humoral immune responses mouse model AAA induced by elastase, evaluating whether antibodies against modified can be found patients. particles...
مقدمه: اختلال در پروفایل چربی ها و افزایش استرس اکسیداتیو در مبتلایان به دیابت و سندرم متابولیک شایع است. هدف این پژوهش، بررسی اثر ملاتونین بر اختلال لیپیدهای پلاسما و میزان mda در کلیه، قلب و کبد در موش های تغذیه شده با مقادیر بالای فروکتوز بود. مواد و روش ها: ۲٤ سر موش صحرایی نر در سه گروه تقسیم شدند، گروه کنترل: غذا (پلت ) و آب، گروه فروکتوزی: غذا و محلول۱٠% فروکتوز، گروه ملاتونین: غذا و محل...
Abstract Background The impact of single-dose mass drug administration (MDA) ivermectin for onchocerciasis on mosquito populations was investigated in Ogun State, Nigeria. Methods Indoor and outdoor collection mosquitoes carried out two intervention (IC) control communities (CC) at three different periods: pre-MDA (baseline), 2–3 days after MDA 13–14 MDA. density parity rate female Anopheles Cu...
The most known definition of reverse engineering was given by Chikofsky and Cross (1990): “the process of analyzing a subject system to (i) identify the system’s components and their interrelationships and (ii) create representations of the system in another form or at a higher-level of abstraction”. Reverse engineering is the process of discovering and understanding software artifacts or syste...
Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease[S]
Autoantibodies specific for malondialdehyde-modified LDL (MDA-LDL) represent potential biomarkers to predict cardiovascular risk. However, MDA-LDL is a high variability antigen with limited reproducibility. To identify peptide mimotopes of MDA-LDL, phage display libraries were screened with the MDA-LDL-specific IgM monoclonal Ab LRO4, and the specificity and antigenic properties of MDA mimotope...
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