OBJECTIVE To compare multiple serum markers for their ability to detect active disease in patients with GCA and in those with PMR. METHODS Twenty-six markers related to immune cells that may be involved in GCA and PMR were determined by ELISA and multiplex assay in the serum of 24 newly diagnosed, untreated GCA/PMR patients, 14 corticosteroid (CS)-treated GCA/PMR patients in remission and 13 ...

Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria. Colistin is a cationic polypeptide antibiotic and acts as the last line of defense for treatment of carbapenem-resistant bacteria. Very recently, a new plasmid-borne colistin resistance g...

OBJECTIVE In this study, we evaluated clinical and epidemiologic features of our giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) patients. METHODS We retrospectively recorded down the general features of patients with GCA and PMR diagnosed at our center within the last 6 years. The incidence rates per 100000 aged > or =50 were calculated. In addition, we reported the frequencies o...

The diagnosis of polymyalgia rheumatica (PMR), characterized by proximal pain and stiffness, is often uncertain owing to PMR mimics, such as rheumatoid arthritis (RA), spondyloarthritides, inf lammatory myopathies connective tissue diseases and vasculitis – all of which can present with the polymyalgic syndrome in the elderly. Inflammatory markers are often discordant with disease activity and ...

OBJECTIVE To develop a composite score for measurement of disease activity in polymyalgia rheumatica (PMR) and assess its internal and external validity. METHODS A PMR activity score (AS) was designed and assessed for internal and external validity in two patient cohorts: 57 international patients evaluated primarily for development of the PMR-AS at baseline, weeks 4 and 24; and for validatio...

OBJECTIVES Evidence of the association of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) with the full range of cardiovascular diseases (CVDs) is limited. We examined their relationship with the first clinical presentation of the 12 most common CVDs in an unselected population-based cohort of men and women. METHODS We analysed CArdiovascular disease research using LInked Bespoke ...

Polymyalgia rheumatica (PMR) is considered to be a benign disease by some, while others think it is a more serious illness which required similar treatment to giant cell arteritis (GCA). The progress of 85 patients with PMR who presented to a district general hospital has been studied in an attempt to study this relationship. Thirty-eight patients had PMR alone, and 14 developed PMR and GCA wit...

From the Center for Cardiovascular Disease Prevention (ADP, NRC, PMR, JEB), the Donald W. Reynolds Center for Cardiovascular Research (ADP, NRC, PMR), the Leducq Center for Molecular and Genetic Epidemiology of Cardiovascular Disorders (PMR), the Division of Cardiovascular Medicine (PMR) and Preventive Medicine (ADP, NRC, JEM, PMR, JEB), Brigham and Women’s Hospital and Harvard Medical School, ...

OBJECTIVE To investigate the incidence of new cancer diagnoses in a community sample of patients with polymyalgia rheumatica (PMR). METHODS All incident cases of PMR in the UK General Practice Research Database (GPRD) (1987-99), without pre-existing cancer or vascular disease and treated with corticosteroids (n=2877) were matched with up to five age, sex and GP practice patients without PMR (...

Polymyalgia rheumatica (PMR) is a well-defined acute musculoskeletal inflammation of ageing people and characterized by clinical symptoms that may create some difficulties in the differential diagnosis with late (elderly) onset RA (LO-RA or EO-RA, respectively) as well as with LO-RA with PMR-like onset (LO-RA/PMR) [1]. PMR as an inflammatory condition of multifactorial aetiology is generally ch...