Multiple cell-signaling pathways converge to modulate large-conductance, voltage- and Ca2+-sensitive K+ channel (maxi-K channel) activity and buffer cell excitability in human myometrial smooth muscle cells (hMSMCs). Recent evidence indicates that maxi-K channel proteins can target to membrane microdomains; however, their association with other proteins within these macromolecular complexes has...

In this paper, we propose a novel large margin classifier, called the maxi-min margin machine M(4). This model learns the decision boundary both locally and globally. In comparison, other large margin classifiers construct separating hyperplanes only either locally or globally. For example, a state-of-the-art large margin classifier, the support vector machine (SVM), considers data only locally...

As with many min-max characterizations, proving one of the inequalities is straightforward. For any U ⊆ S and I ∈ I1 ∩ I2, we have |I| = |I ∩ U |+ |I ∩ (S \ U)| ≤ r1(U) + r2(S \ U), since I ∩ U is an independent set in I1 and I ∩ (S \ U) is an independent set in I2. Therefore, maxI∈I1∩I2 |I| ≤ minU∈S (r1(U) + r2(S \ U)). The following important examples illustrate some of the applications of th...

The Multi-Armed Bandit(MAB) problem is named after slot machine games. When playing slot machines, one player has to decide which machine to play, in which order to play them and how many times to play each machine. After the choice, that specific machine will offer a random reward from a probability distribution, and the player’s target is to maximize the sum of rewards earned through a sequen...

With the rapid growth of vigilance that cognitive radio participate an essential task in wireless communication to resolve the spectrum scarcity vs. under-utilization dilemma owing to the dormant spectrum supervision policies. In this study, we explore the innovative scenario that the secondary user frequently has to trade off between two goals at the same time: one is to maximize its own throu...

abstract soil nutrient management with efficient fertilizer use has an important role on maximizing yield and environmental effects. in this study game theory is applied to identify the nutrient proportion for corn production in kooshkak in fars province, iran, in 2008-2009. cost of fertilizer combinations and production of corn are the players of the game. a goal programming was applied to obt...

Grunnet, Morten, Hans-Günther Knaus, Christina Solander, and DanA. Klaerke. Quantification and distribution of Ca21-activated maxi K1 channels in rabbit distal colon. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G22– G30, 1999.—The Ca21-activated maxi K1 channel is an abundant channel type in the distal colon epithelium, but nothing is known regarding the actual number and precise loc...

This study shows the in vivo neuroprotective effect of cilostazol against cerebral ischemic injury evoked by subjecting rats to 2-h occlusion of middle cerebral artery (MCAO) followed by 24-h reperfusion. We observed the signaling pathway by which cilostazol suppressed MCAO-induced increased phosphorylation of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) and apoptosis via in...

Children at the age of 3 or less invariably got the answer wrong and assumed that Maxi would look for the chocolate in the green cupboard where they knew it was. Even children aged 4-5 had only a one third chance of correctly answering this question or an analgous question involving Maxi and his brother (who also wants the chocolate and whom Maxi wants to deceive). Children aged 6 or more were ...

Large conductance chloride (maxi-Cl(-)) currents have been recorded in some cells, but there is still little information on the molecular nature of the channel underlying this conductance. We report here that tweety, a gene located in Drosophila flightless, has a structure similar to those of known channels and that human homologues of tweety (hTTYH1-3) are novel maxi-Cl(-) channels. hTTYH3 mRN...