A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L(-1) HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability st...

controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (hpmc) as the matrix former. the effects of the viscosity grades of hpmc and hpmc/lactose ratio and ethylcellulose (ec)/sodium carboxymethylcellulose (nacmc) and their concentrations on the release behavior of phenobarbital from hpmc matrices were invest...

In this study, we examined a possible use of a surface-deacetylated chitin nano-fiber (SDCH-NF) and hyaluronic acid (HA) interpolymer complex (IPC) tablet as a potential antioxidative compound in extended-release matrix tablets. The antioxidant properties of untreated chitin (UCH), SDCH-NF, and HA were examined using N-centered radicals derived from 1,1'-diphenyl-2-picrylhydrazyl (DPPH) and 2,2...

Article history: Received on: 23/05/2013 Revised on: 05/07/2013 Accepted on: 01/09/2013 Available online: 30/09/2013 The main objective of the present work was to develop sustained release matrix tablets of Atenolol. To reduce the frequency of administration and to improve the patient compliance, a once daily sustained release formulation of Atenolol is desirable. So sustained release Matrix Ta...

Article history: Received on: 10/12/2012 Revised on: 29/12/2012 Accepted on: 15/01/2013 Available online: 28/01/2013 The aim of the present work was to develop and evaluate colon specific sustained release tablet using levetiracetam (LEV), microbially degradable polymeric carrier (pectin), coating material and matrix forming polymers. The colon targeted tablet was prepared by wet granulation te...

Metformin hydrochloride (metformin HCl) was formulated as a hydrophobic matrix sustained release tablet employing wax materials and the sustained release behavior of the fabricated tablet was investigated. Sustained release matrix tablets containing 500 mg metformin HCl were developed using different bees wax combinations. The tablets were prepared by wet granulation technique. The formulation ...

The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on drug release from valproic acid-sodium valproate matrix tablets prepared with w...

This study concerns the evaluation of natural gum copal and gum damar as novel sustained release matrix forming materials in tablet formulation. Along with the physicochemical properties, gum copal and gum damar were characterized for molecular weight, polydispersity index and glass transition temperature. Matrix tablets were prepared by wet granulation technique using isopropyl alcohol as a gr...