Mantle cell lymphoma (MCL) is a rare and incurable subtype of non-Hodgkin's lymphoma that generally affects older individuals. However, the use of high-dose therapy and autologous stem cell transplant has improved significantly the prognosis of this hematological malignancy, but at the cost of increased toxicities, such as acute toxic death and secondary malignancies. But thanks to a rising und...

After the abandonment of Mapungubwe, Limpopo Valley was reoccupied first by Sotho people, making Icon pottery, and then Kalanga speakers Khami pottery. The senior chief, in this case Twamamba, based at Machemma about 60 km to south, while several petty chiefs administered various portions valley itself. Because fluctuating rainfall, occupations both people occurred pulses during higher rainfall...

city growth and environmental difficulties last decades leads the art of urban design and development think more precisely and new approaches for conserving environment and developing urban areas have been evolved.the present study deals with concepts related to ecology in the city and in particular the theory of ecological urbanism and its criteria is expressed. also theory and characteristics...

City growth and environmental difficulties last decades leads the art of urban design and development think more precisely and new approaches for conserving environment and developing urban areas have been evolved.The present study deals with concepts related to ecology in the city and in particular the theory of Ecological Urbanism and its criteria is expressed. Also theory and characteristics...

In this study, we define the genetic landscape of mantle cell lymphoma (MCL) through exome sequencing of 56 cases of MCL. We identified recurrent mutations in ATM, CCND1, MLL2, and TP53. We further identified a number of novel genes recurrently mutated in patients with MCL including RB1, WHSC1, POT1, and SMARCA4. We noted that MCLs have a distinct mutational profile compared with lymphomas from...

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117 As Head points out, “the cultural heritage sector uses the classical geographical sense of landscapes as modified by human activity, with an emphasis on ancient monuments and historical buildings.” In other words, cultural landscape heritage is generally approached in terms of material or morphological artifacts that constitute culturally determined physical, and therefore visible, modifica...

Research on cultural products suggest that there are substantial cultural variations between East Asian and European landscape masterpieces and contemporary members' landscape artwork (Masuda et al., 2008c), and that these cultural differences in drawing styles emerge around the age of 8 (Senzaki et al., 2014b). However, culture is not static. To explore the dynamics of historical and ontogenet...

Mantle cell lymphoma (MCL) is clinically characterized by its heterogenous behavior with courses ranging from indolent cases that do not require therapy for years to highly aggressive MCL very limited prognosis. A better understanding of the complex biology has already led approval several innovative agents, expanding landscape therapies and improving therapeutic options especially refractory o...