To ensure final product safety, clearance of host cell DNA from the drug substance is essential in the manufacturing process for therapeutic proteins and monoclonal antibody (MAB) drugs. We have developed and validated an automated process for monitoring clearance of Chinese Hamster Ovary (CHO) DNA impurities during the capture and polishing steps of downstream processing. This method, which el...

Conventional robots find their limitation if the task execution requires a level of perception, dexterity and decision making which cannot be met technically in a costeffective or a robust way. However, within the otherwise manual task execution less demanding subtasks may still be carried out automatically. A safe and flexible co-operation between robot and operator may be a promising way to a...

Textiles is one the nation’s oldest industries, dating back to be beginning of the American industrial revolution in the 1790s. Despite perceptions of the decline of U.S. textile manufacturing in the face of offshore competition, the industry remains one of the largest, most diverse, and dynamic segments of the U.S. manufacturing sector. This manual represents a comprehensive history of the U.S...

The optimization of existing manufacturing systems is a challenging and highly complex task, requiring highquality information about the current system. Currently, acquiring such information involves tedious and to a large extend manual work. In this paper we present an ongoing joint project effort bringing together cognitive robotics and planning and control of manufacturing systems to create ...

At present, the fruit picking in most countries still largely relies on manual operation. Manual fruit picking can protect the fruits from damage during the operation process. However, it is time-consuming and labor-intensive, and poses a potential safety risk to the workers while working at heights not reachable. Therefore, a variety of fruit picking machines and platforms have been developed ...

In a number of manufacturing applications, parts of circular cross-section must be centered for optimal processing or measurement. However, part form is never perfect, making accurate determination of the “centered” state of a part difficult. Imperfect inputs to the manufacturing process such as roughprocessed parts, deformation due to heat treatment, or raw formed materials present difficulty ...

Advancements in robotic and automation industries have influenced many manual manufacturing operations. With a great level of success, robots have taken over from man in many processes such as part manufacturing, transfer and assembly. However, in other traditionally manual operations such as polishing, automation has only partially been successful, typically limited to parts with simple geomet...

A simple procedure for manufacturing microchips containing various gel-immobilized compounds is described. A gel photopolymerization technique is introduced to produce micromatrices of polyacrylamide gel pads (25 x 25 x 20 microm and larger) separated by a hydrophobic glass surface. A pin device for the manual application of a compound in solution onto the activated polyacrylamide gel pad for i...