BACKGROUND Bipolar disorders (BD) are of particular public health significance as they are prevalent, severe and disabling, and often associated with elevated risks of premature mortality. The aim of this concise overview is to investigate the role of asenapine in the treatment of manic and mixed states associated with BD type 1 disorder. METHOD MedLine, Excerpta Medica and PsycINFO searches ...

Insight impairment is common early in the course of psychosis. Most studies have focused on the relationship between insight and depression, although manic symptoms are also frequent in psychoses. The main aim of this study was to examine the relationship between insight dimensions and manic and depressive symptoms in first-episode psychosis. A group of inpatients in their first psychotic episo...

Background The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment options in terms of efficacy and tolerability/safety. Material and Methods The PRISMA method was used in the literature search with the combination of the words 'bipolar,' 'manic,' 'mania,' 'manic depression,' and 'manic depressive' with 'randomized,'...

The separation of manic depressive illness from schizophrenia was an important diagnostic task undertaken early on by Kraepelin (1896, 1919) who saw schizophrenia (“dementia praecox”) as a psychotic illness and a thought disorder, characterised by a steady downhill in cognition leading to chronic dementia, whereas manic depressive illness was seen as an episodic affective disorder with intermit...

OBJECTIVE Bipolar disorder is a severe, recurrent, and often chronic psychiatric illness associated with significant functional impairment, morbidity, and mortality. Creatine kinase is an important enzyme, particularly for cells with high and fluctuating energy requirements, such as neurons, and is a potential marker of brain injury. The aim of the present study was to compare serum creatine ki...

Manic episodes of bipolar disorder can lead to uncritical behavior and delusional psychosis, often with destructive consequences for those affected their surroundings. Early detection intervention a manic episode are crucial prevent escalation, hospital admission, premature death. However, people may not recognize that they experiencing symptoms, such as euphoria increased productivity also det...

BACKGROUND Whilst cannabis use appears to be a causal risk factor for the development of schizophrenia-related psychosis, associations with mania remain relatively unknown. This review aimed to examine the impact of cannabis use on the incidence of manic symptoms and on their occurrence in those with pre-existing bipolar disorder. METHODS A systematic review of the scientific literature using...

The separation of manic depressive illness from schizophrenia was an important diagnostic task undertaken early on by Kraepelin (1896, 1919) who saw schizophrenia (“dementia praecox”) as a psychotic illness and a thought disorder, characterised by a steady downhill in cognition leading to chronic dementia, whereas manic depressive illness was seen as an episodic affective disorder with intermit...

Renaming disorders to change public beliefs and attitudes remains controversial. This study compared the potentially destigmatising effects of renaming schizophrenia with the effects of renaming bipolar disorder by comparing the label 'schizophrenia' to 'integration disorder', and 'bipolar disorder' to 'manic depression', in 1621 lay participants. 'Bipolar disorder' was associated with less fea...

BACKGROUND Abnormalities in the cyclic adenosine monophosphate (cAMP)-dependent phosphorylation system have been recently reported in patients with bipolar disorder. We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed patients with ...