BACKGROUND Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism. METHODS Archived blood samples, collected from 332 Mexican women at delivery, were analyzed for manganese. We evaluated associations of manganese with functional variants in three candidate iron metabolism genes: ...

The removal of manganese and humic acid (HA) by two nanofiltration membranes, TFC-SR2 and TFC-SR3, was investigated in order to highlight the influence of speciation on manganese and HA retention. Manganese speciation and complexation with HA were modelled to understand how speciation could affect NF removal mechanisms. The behaviour of the two membranes was drastically different for manganese ...

We measured the manganese content of mononuclear blood cells and the manganese concentrations in whole blood and plasma from 31 healthy volunteers and 25 patients receiving total parenteral nutrition (TPN) (i.e., no dietary manganese). The manganese content (mean +/- 2 SD) of mononuclear blood cells and the manganese concentration in whole blood and plasma in the healthy volunteers were 8.84 +/...

According to the publication by US Minerals Survey in 1999, the total reserve of manganese ore in the world is 0.66 billion tons. See Table 1. Table 1 World Manganese ore reserve(Mn metal weight, million tons) __________________________________________ Name of counties Reserve in 1999 __________________________________________ South Africa 370 Ukraine 135 China 40 India 34 Australia 26 Gabon 20...

Concerns exist as to whether individuals may be at greater risk for neurotoxicity following increased manganese (Mn) oral intake. The goals of this study were to determine the equivalence of 3 methods of oral exposure and the rate (mg Mn/kg/day) of exposure. Adult male rats were allocated to control diet (10 ppm), high manganese diet (200 ppm), manganese-supplemented drinking water, and mangane...

BACKGROUND Environmental manganese exposure has been associated with adverse neurodevelopmental outcomes among school-aged children; yet, few studies have evaluated prenatal exposure. OBJECTIVES Our study examines associations between prenatal manganese concentrations and placental transfer of manganese with neurodevelopment in 224 2-y-old children residing near the Tar Creek Superfund Site. ...

BACKGROUND Manganese is an essential element, but excessive manganese exposure has neurotoxic effects. OBJECTIVE To examine blood manganese levels in the general population with respect to sex, age, race/ethnicity, pregnancy and menauposal status, as well as levels of trace elements in blood. METHODS We used data from the National Health and Nutrition Examination Survey, a national survey o...

The essential trace elements zinc and manganese have been noted as factors in brain disease since the Twenties. The combined use of zinc and manganese in schizophrenia is based on: 1) Increased urinary excretion of copper when both zinc and manganese are given orally 2) Zinc alone causes a decrease in blood manganese and 3) The double deficiency of zinc and manganese frequently is found in pati...

this study was conducted to evaluate the relative bioavailability value of mn proteinate and mn oxide in broiler chicks. a total of 432 day-old cobb 500 commercial male broiler chicks were randomly distributed into nine treatments with eight replicate pens of six chicks each. in a completely randomized design experiment with a 2×4 factorial arrangement of two manganese sources (proteinate and r...

There is considerable evidence that the prion protein binds copper. However, there have also been suggestions that prion protein (PrP) binds manganese. We used isothermal titration calorimetry to identify the manganese binding sites in wild-type mouse PrP. The protein showed two manganese binding sites with affinities that would bind manganese at concentrations of 63 and 200 mum at pH 5.5. This...