The administration of large doses of estrogen to young male mice was followed by less extensive mammary gland growth than when small amounts of estrogens were given". The areas occupied by the mammary glands of the mice given large doses were often but little larger than the glands of untreated controls, but unlike the controls their mammary glands, although very small, had a few alveoli on the...

A conditional null mutation of peroxisome proliferator-activated receptor-binding protein (PBP) gene was generated to understand its role in mammary gland development. PBP-deficient mammary glands exhibited retarded ductal elongation during puberty, and decreased alveolar density during pregnancy and lactation. PBP-deficient mammary glands could not produce milk to nurse pups during lactation. ...

histological grading is a good parameter to stratify tumors according to their biological aggressiveness. the elston and ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. the aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. the samples included ...

The present experiments were performed to determine the roles of estrogen receptors α and β (ERα and ERβ) in normal and neoplastic development in the mouse mammary gland. In wild-type mice, in vivo administration of estradiol (E) + progesterone (P) stimulated mammary ductal growth and alveolar differentiation. Mammary glands from mice in which the ERβ gene has been deleted (βERKO mice) demonstr...

Mammary glands were successfully transplanted from randombred Sprague-Dawley rats to recipients, irrespective of whether the transplants were autografts or homografts. Homologous transplantation of mammary glands was successful in both littermates and nonlitterJDates. Surviving grafts had the histological appearance of nonnalmammary glands and functioned like the nOrJDal mammary glands of the r...

Levels of 2-methoxyestradiol (2ME(2)), an endogenous metabolite of estradiol, are highly elevated during late stages of pregnancy when mammary glands have differentiated with the formation of alveolar structures producing milk proteins. Based upon our previous demonstration that 2ME(2) induces mammary ductal dilation associated with expression of mammary differentiation markers when administere...

During the involution of mammary glands, epithelial cells undergo apoptosis and are cleared for the next cycle of lactation. The clearance of apoptotic epithelial cells is mediated by neighboring epithelial cells and by macrophages that migrate into the mammary glands. Here, we report that milk fat globule EGF factor 8 (MFG-E8), a secreted glycoprotein that binds to apoptotic cells by recognizi...

background: hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. the current study was designed to evaluate dose-dependent effect of chlorpromazine (cpz) on hormonal changes and uterine horn histological structure in rats. moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. methods: albino wistar r...

Objective- The aim of this study was to determine the normal ultrasonographic and morphologic appearance of mammary gland and teat in Caspian mares during lactation and dry period. Design- Experimental study. Animals- Seven mature Caspian mares Procedures- Using a 6.5-8.5 MHz linear transducer the ultrasonographic appearance of lactating and dry mammary glands was determined in 7 mature Casp...