A straightforward stereoselective and enantiodivergent cyclization strategy for the construction of γ-lactams is described. The cyclization strategy makes use of chiral malonic esters prepared from enantiomerically enriched monoesters of disubstituted malonic acid. The cyclization occurs with the selective displacement of a substituted benzyl alcohol as the leaving group. A Hammett study illust...

Polyketides are biosynthesized through consecutive decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes. Individual malonic acid derivatives are typically required to be activated as coenzyme A-thioesters prior to their enzyme-catalyzed transfer onto the polyketide synthase. Co...

I s nanoscience the “first full embodiment of post-academic science”? Have many of the traditional core values of publicly funded university science been eroded to the point where they are now “part of a scientific mythology”? And is it “morally bankrupt” to draw a distinction between ‘pure’ and ‘applied’ science? These claims, which were all made in a recent commentary in Nature Nanotechnology...

organic acidemias, also known as organic acidurias, are a group of disorders characterized by increased excretion of organic acids in urine. they result primarily from deficiencies of specific enzymes in the breakdown pathways of amino acids or from enzyme deficiencies in beta oxidation of fatty acids or carbohydrate metabolism. organic acids also are found in the urine of some patients with mi...

The development of oneand two-dimensional Turing patterns characteristic of the chlorite-iodide-malonic acid/indicator reaction occurring in an open gel continuously fed unstirred reactor is investigated by means of various weakly nonlinear stability analyses applied to the appropriately scaled governing chlorine dioxide-iodine-malonic acid/indicator reaction-diffusion model system. Then the th...

1. It has been shown that Penicillium charlesii continues to synthesize galactocarolose when l-malic acid, malonic acid, succinic acid, fumaric acid, maleic acid or oxaloglycollic acid is substituted for dl-tartaric acid in the Raulin-Thom nutrient medium. 2. The quantity of galactocarolose synthesized per g. of mycelia was markedly decreased by substitution of l-malic acid, malonic acid, succi...

We discuss the design of reaction-diffusion systems that display a variety of spatiotemporal patterns. We also consider how these patterns may be controlled by external perturbation, typically using photochemistry or temperature. Systems treated include the Belousov-Zhabotinsky (BZ) reaction, the chlorite-iodide-malonic acid and chlorine dioxide-malonic acid-iodine reactions, and the BZ-AOT sys...

Three enclosures (10 x 10 x 1.5-1.3 m in depth) were set beside Dianch Lake, Kunming, People's Republic of China, for the period from July 28 to August 26, 2002. The enclosures were filled with cyanobacterial (Microcystis aeruginosa) water bloom-containing lake water. Lake sediment that contained macrophytes and water chestnut seeds was spread over the entire bottom of each enclosure. Initially...