Introduction: Multiple Sclerosis (MS) is a condition that affects young adults typically aged 20-40 years, and involves inflammation and demyelination of neural axons in the brain and nervous system. Magnetization transfer (MT) imaging studies the interaction between water and macromolecular (e.g.Protein in Myelin) protons and can be a useful in studying the changes in normal appearing white ma...

OBJECTIVE To validate the use of the magnetization transfer ratio (MTR) as a practical imaging marker of demyelination and remyelination in acute multiple sclerosis lesions. DESIGN Case study. SETTING University hospital multiple sclerosis clinic. Patients Six patients with relapsing-remitting multiple sclerosis and acute gadolinium-enhancing lesions were studied serially using a quantitati...

Magnetization transfer (MT) imaging techniques were implemented to study a clip compression model of spinal cord injury (SCI) in the rat. The purpose of this study was to determine if the magnetization transfer ratio (MTR) could be used to classify the stage and severity of SCI. Two clip compression injuries were studied: mild SCI and severe SCI. MTRs were determined for gray matter (GM) and wh...

Specific Aim 2: To determine whether use of hyperbaric oxygen impacts MRI parameters. MRI parameters will be evaluated at baseline and 6 months to determine: 2a) Thalamic volume loss 2b) Magnetization transfer ratio (MTR) change in baseline lesions. 2c) Magnetization transfer (MT) histogram whole brain and normal appearing brain tissue change (white matter and gray matter). 2d) Accumulation of ...

BACKGROUND AND PURPOSES MR imaging is now widely used to monitor disease progression in patients with multiple sclerosis (MS). The purpose of this study was to explore the relationship between disability status and existing and new MR parameters in MS patients. METHODS Forty-one patients with clinically definitive MS were studied. MR imaging included T2- and T1-weighted imaging as well as gra...

BACKGROUND AND PURPOSE Current imaging does not permit quantification of neural injury after traumatic brain injury (TBI) and therefore limits both the development of new treatments and the appropriate counseling of patients concerning prognosis. We evaluated the utility of magnetization transfer ratio (MTR) and proton MR spectroscopy in identifying patients with neuronal injury after TBI. ME...

BACKGROUND AND PURPOSE Hepatic encephalopathy in cirrhotic patients may be the clinical manifestation of disturbed cerebral cell volume homeostasis. The aim of this study was to investigate the presence of significant changes in magnetization transfer ratio (MTR) values, which could reflect an increase in free water within the brain of patients with liver cirrhosis, and to correlate these findi...

Previous studies suggested that magnetization transfer ratio (MTR) histograms are highly correlated with other magnetic resonance imaging (MRI) measures and can be used as a reliable method for quantifying overall disease burden in multiple sclerosis (MS). However, the relative influence of burden and severity of macroscopic MS lesions and degree of brain atrophy on various MTR histogram parame...

The aim of the study was to assess potential changes in structural integrity of the brain in adolescent patients with Anorexia Nervosa (AN) using the magnetization transfer imaging technique and re-evaluating after nutritional rehabilitation was accomplished. Magnetization transfer ratio (MTR) was used for the detection and quantification of histological changes to the white matter of 9 adolesc...

BACKGROUND AND PURPOSE Cerebral white matter (WM) hyperintensities are a frequent finding in elderly people, and lowering of cerebral magnetization transfer ratio (MTR) has been observed. The aim of this study was to assess the relationship between age-related WM hyperintensities and MTR changes in the brain. METHODS We performed MR imaging in a group of young subjects, a group of elderly ind...