The M42 Active Traffic Management project will introduce controlled use of the hard shoulder to the UK motorway. This paper describes some of the challenges encountered and solutions adopted in carrying out risk assessment on this project. These include the development of a methodology for demonstrating, in advance of opening the scheme, that the safety of the modified motorway will be equivale...

AZD7325 [4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide] is a selective GABAAα2,3 receptor modulator intended for the treatment of anxiety disorders through oral administration. An interesting metabolic cyclization and aromatization pathway led to the tricyclic core of M9, i.e., 2-ethyl-7-(2-fluoro-6-methoxyphenyl)pyrimido[5,4-c]cinnolin-4(3H)-one. Further oxidative metabo...

Abstract This study compares two tools, HSS M42 and TiN Coated twist drill bits, in order to determine which tool has the better material removal rate (MRR). Drill bits were of high speed steel (HSS M42) use Novel coating Titanium Nitride on this study. The machining is done a experimental specimen made aluminium alloy AA6063. both tools measured CNC drilling sets 20 specimens each. Spindle spe...

We present high angular-resolution (12′′ − 26′′) large-scale mapping (19′× 22′) of the Orion A molecular complex in the N = 1 → 0 and N = 2 → 1 rotational transitions of the CN radical. The CN emission is not only confined to the molecular ridge and the optical bar, but it reveals filamentary emission toward the north and southwest of the Trapezium cluster and surrounding M43. The morphology an...