Smart-M3 is an open-source platform that provides the multi-agent distributed application with the shared view of dynamic knowledge and services in ubiquitous computing environments. Smart-M3 semantic information broker maintains smart space in low-level terms of triples, based on resource description framework (RDF). Smart-M3 application consists of agents (also known as Smart-M3 knowledge pro...

The mouse MHC class I-b molecule H2-M3 has unique specificity for N-formyl peptides, derived from bacteria (and mitochondria), and is thus a pathogen-associated molecular pattern recognition receptor (PRR). To test whether M3 was selected for this PRR function, we studied M3 sequences from diverse murid species of murine genera Mus, Rattus, Apodemus, Diplothrix, Hybomys, Mastomys, and Tokudaia ...

The variant form of acute promyelocytic leukaemia (AML-M3) possesses its own characteristic morphology, although usually a few of the cells may have cytoplasmic features of typical AML-M3. In contrast to typical AML-M3, this M3-variant form commonly presents with hyperleucocytosis. As in typical AML-M3, disseminated intravascular coagulopathy (DIVC) occurs in the M3-variant. A boy with this mor...

Chemokines are involved in recruitment and activation of hematopoietic cells in sites of infection and inflammation. The M3 gene of the gamma-herpesvirus gammaHV68 encodes an abundant secreted protein that binds CC chemokines with high affinity. We report here that this gene is essential for efficient induction of lethal meningitis by gammaHV68. An M3 mutant gammaHV68 (gammaHV68-M3.stop) was 10...

α1 α2 α3 α4 inModR. If the rows are exact, then the following statements hold. (1.3.a) If γ2 and γ4 are injective and γ1 is surjective, then γ3 is injective. (1.3.b) If γ2 and γ4 are surjective and γ5 is injective, then γ3 is surjective. Proof. First we prove (1.3.a). So suppose that γ2 and γ4 are injective and γ1 is surjective. Start with m3 ∈ M3 with the property that γ3(m3) = 0. The goal is ...

We used a new monoclonal antibody (mAb 130) to analyze the intracellular trafficking and surface expression of H2-M3, the major histocompatibility complex class Ib molecule that presents N-formylated peptides to cytotoxic T cells. M3 surface expression is undetectable in most cell types due to the paucity of endogenous antigen. M3 is induced on the cell surface by addition of high-affinity N-fo...

Negative chronotropic and smooth muscle contractile responses to the nonselective muscarinic agonist carbamylcholine were compared in isolated tissues from M3 muscarinic receptor knockout and wild-type mice. Carbamylcholine (10-3.0x10M) induced a concentration-dependent decrease in atrial rate that was similar in atria from M3 receptor knockout and wild-type mice, indicating that M3 receptors w...