Lysosomes are the main degradation organelles in eukaryotic cells, and their dysfunction is closely related to Alzheimer’s disease (AD). Our goal identify lysosomal molecular subtype of AD explore mechanisms. By differential analysis, 50 differentially expressed genes were identified. R-package “ROCR” was used calculate ROC curves AUC values for genes. “ConsensusClusterPlus” consistent clusteri...

The endoplasmic reticulum (ER) comprises morphologically and functionally distinct domains, sheets interconnected tubules. These domains undergo dynamic reshaping, in response to changes the cellular environment. However, mechanisms behind this rapid remodeling within minutes are largely unknown. Here, we report that ER is actively driven by lysosomes, following lysosome repositioning nutrition...

dacarbazine (dtic) is a synthetic chemical antitumor agent which is used to treat malignant melanoma and hodgkin’s disease. dtic is a prodrug which is converted to an active form undergoing demethylation by liver enzymes. the active form prevents the progress of disease via alkylation of dna strand. in the structure of this drug, the imidazole ring, a triazen chain and carboxamide group exist. ...