Significance Social behavior (SB) is a fundamental hallmark of human interaction. Repeated administration low doses the 5-HT 2A agonist lysergic acid diethylamide (LSD) in mice enhances SB by potentiating and AMPA receptor neurotransmission mPFC via an increasing phosphorylation mTORC1, protein involved modulation SB. Moreover, inactivation glutamate impairs nullifies prosocial effects LSD. Fin...