background: an increase in the number of intraepithelial lymphocytes (iel) in the duodenal mucosa is an important criterion for the histological diagnosis of celiac disease (cd). we determined the normal range for intraepithelial lymphocytes (iel) in the second part of duodenum in healthy iranian population. materials and methods: four biopsy samples of the endoscopically normal appearing mucos...

t lymphocytes that are involved in cellular mediated immunity include two types known as tcd8+ (cytotoxic t lymphocytes) and tcd4+ (helper t lymphocytes). tcd4+ has four main subtypes, including th1, th2, th17, and treg lymphocytes.th17 lymphocytes play a role in defense against microbes that th1 and th2 lymphocytes have not the ability to respond to them. the most important cytokines, which ar...

background lichen planus is a disease with unknown etiology that affects the skin and the mucous membranes. immune dysregulation in the pathogenesis of oral lichen planus (olp) is well-known phenomenon. objectives in this study, we compared the levels of the peripheral blood t lymphocytes between patients with olp and control group. patients and methods in this study, 32 and 16 patients respect...

Background: Neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR) and platelet-lymphocyte ratio (PLR) have a prognostic value in several types of diseases such as cancers and they vary in different races. So, we aimed to evaluate the normal range of these markers among healthy people to determine the normal value in Iranian population. Methods: In the present study, cross-sectiona...

backgrounds: seminoma is frequently observed in human and canine testes especially in cryptorchids. canine and human seminomas are typically associated with leukocytic infiltration. objectives: we aimed to identify the type of lymphocytes that infiltrate to seminomas. methods: tumor infiltrating lymphocytes were evaluated by immunohistological techniques in 5 dogs with diffuse seminoma. routine...

Background: Iron is an essential trace element in cell proliferation. Several investigations demonstrate that iron deprivation inhibits cell proliferation. However, the impact of iron on telomerase activity of activated lymphocytes remains unexplained to date. Objective: In this study, the effect of iron on the proliferation and telomerase activity of lymphocytes stimulated by phytohemagglutini...

Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic and HAM/TSP is the most common clinical manifestation of the virus. HAM/TSP is an inflamma...

allergic asthma is a complex and chronic inflammatory airway disease. interleukin-17 is a pro-inflammatory cytokine which plays critical role in the pathogenesis of allergic asthma. it has been reported that β-arrestin2 regulated the development of allergic asthma at a proximal step in the inflammatory cascade. in this study, the influence of β-arrestin2 on interleukin-17 production and express...

background : an elevation in the mean percentages of the gamma delta t lymphocytes per total t cells in the epithelium of the small intestine has a diagnostic value for celiac disease.  this study aimed to measure the percentages of the peripheral blood gamma delta t lymphocytes in the adults' celiac disease and healthy controls. materials and methods: in this case-control study the absolute nu...