نتایج جستجو برای: lymphocyte antiproliferative factor
تعداد نتایج: 904013 فیلتر نتایج به سال:
Lymphocyte recognition of antigen by the antigen-specific T cell receptor (TCR) and coreceptor complexes rapidly alters the cell's adhesive properties facilitating high avidity cell-ligand interactions necessary for lymphocyte development and function. Here, we report the expression of CD81 (target of antiproliferative antigen [TAPA]-1) on human thymocytes and the physical association of CD81 w...
BACKGROUND The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthritis (RA) treatment. However, a considerable proportion of RA patients are refractory to LEF. Here, we investigated lapachol (LAP), a natural naphthoquinone, as a potential DHODH...
This study tests the hypothesis that the clinical response to cyclosporin therapy of patients with chronic severe asthma is related to the sensitivity of their T-lymphocytes to the antiproliferative effects of cyclosporin in vitro. In a previous study, we observed such a relationship with glucocorticoids and the same lectin-driven proliferation assay was used in the present study. Peripheral bl...
Over several decades, topical corticosteroids (TCs) have been used in the treatment of various dermatoses such as psoriasis, contact dermatitis, and eczema, among others. The TCs act by reducing inflammation irritation after application. therapeutic effect is bestowed through their diverse biologic properties anti-inflammatory, antiproliferative, vasoconstrictive, antimitotic activity, its role...
To determine the functional significance of the endogenous expression of the epidermal growth factor (EGF) and transforming growth factor-alpha genes in T-47D, human breast cancer cells, we have examined the effects of two types of antiproliferative agents, progestins and antiestrogens, on the expression of these growth factors and the effects of exogenous EGF on the antiproliferative action of...
Treatment of human K562 erythroleukemia cells with the antiproliferative prostaglandin A1 results in the elevated transcription of two heat shock genes, HSP70 and HSP90. Parallel with increased heat shock gene transcription is the activation of heat shock transcription factor. Heat shock transcription factor levels are induced within 60 min after prostaglandin A1 addition to levels similar to t...
normal 0 false false false en-us x-none ar-sa background: from the thousands of years, metal compounds have been used in medicine for treatment of various diseases including various types of cancers. ruthenium was seen as a promising metal due to its similar kinetics to platinum and its lower toxicity. therefore, we aimed to evaluate the newer mononuclear ruthenium (ii) compounds for antinocice...
Immune suppression during measles accounts for most of the morbidity and mortality associated with the virus infection. Experimental study of this phenomenon has been hampered by the lack of a suitable animal model. We have used the cotton rat to demonstrate that mitogen-induced proliferation of spleen cells from measles virus-infected animals is impaired. Proliferation inhibition is seen in al...
ferulago w. koch. (apiaceae) genus is represented by approximately 50 taxa throughout the world. ferulago species are known as “çakşır” or “çağşır” in turkey and mostly known for their aphrodisiac effects. however recent reports emphasize the activity of various ferulago species against cancer, as well. the aim of this study was to investigate the effect of lyophilized extract of f. mughlea peş...
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