نتایج جستجو برای: lymphocyte activation
تعداد نتایج: 476496 فیلتر نتایج به سال:
Current techniques for lymphocyte transformation are evaluated and criticised. A simple technique, designed to meet these criticisms, is described in detail, with particular reference to lymphocyte separation and scoring methods.
The interactions of phytohemagglutinin (PHA) with normal human lymphocytes were studied utilizing radioiodinated leukoagglutinin (“$I-LPHA) over a concentration spectrum encompassing the entire range of lymphocyte metabolic responses. “jI-LPHA binding was temperature-, pH-, and time-dependent. Ligand association was rapid with at,,* of 3 to 5 min, reaching steady state in 30 min at 22”. Recepto...
It is well known that the activation of lymphoid cells differ significantly depending on their lineage/subset and differentiation stages. Among the variety of cytokines characterized until today, essentially all the cytokines appear not to be strictly specific to any of the subset of lymphocytes. For example, all the interleukins including IL-2, IL-4 and IL-5 are not specific for B or T lymphoc...
B and T lymphocytes, the antigen-specific cells of the immune system, are generally quiescent and require antigen stimulation to progress from the G0 stage of the cell cycle. The immune response to pathogens or foreign substances is initiated from clonotypic receptors on these cells that recognize the antigen and induce a series of signal transduction events. These signals are fundamental in bo...
The biology of lymphocytes is regulated by a large and seemi& growing number of soluble and cell-associated species. A current list includes: interleukins IL l-7, interferons, antigen and perhaps CD4 and cytokines derived from non-lymphoid tissues such as neuropepride, steroid and admnergic hormones. The quality and quantity of regulators present in the B cell milieu during an immunologic insul...
The homing of blood borne lymphocytes into lymph nodes and Peyer's patches is mediated in part by recognition and binding to specialized high endothelial venules (HEV). Here we demonstrate that a rapid pertussis toxin-sensitive lymphocyte activation event can participate in lymphocyte recognition of HEV. In situ video microscopic analyses of lymphocyte interactions with HEV in exteriorized mous...
Central ossifying fibroma is a benign, slow-growing tumor of mesenchymal origin with a predilection for the mandibular premolar and molar areas. The immunophenotype of T cells involved in the antitumor response against this benign tumor is unknown. In this case report, we described a case of a 48-year-old woman presenting with a very large recurrent ossifying fibroma in the mandible, which was ...
Despite an agreement on most issues surrounding models for how lymphocytes are activated and inactivated, and arising out of the 1970 Two Signal Model of lymphocyte activation, Cohn and I have different perspectives on two critical issues concerning the activation of CD4 T cells. One issue is the origin of the first effector T helper (eTh) cells, postulated by both of us to be required to optim...
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