نتایج جستجو برای: lymphatic metastasis

تعداد نتایج: 147018  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Luana Schito Sergio Rey Marco Tafani Huafeng Zhang Carmen Chak-Lui Wong Andrea Russo Matteo A Russo Gregg L Semenza

Lymphatic dissemination from the primary tumor is a major mechanism by which breast cancer cells access the systemic circulation, resulting in distant metastasis and mortality. Numerous studies link activation of hypoxia-inducible factor 1 (HIF-1) with tumor angiogenesis, metastasis, and patient mortality. However, the role of HIF-1 in lymphatic dissemination is poorly understood. In this study...

2014
Zhiwen Xiao Guopei Luo Chen Liu Chuntao Wu Liang Liu Zuqiang Liu Quanxing Ni Jiang Long Xianjun Yu

As the most challenging human malignancies, pancreatic cancer is characterized by its insidious symptoms, low rate of surgical resection, high risk of local invasion, metastasis and recurrence, and overall dismal prognosis. Lymphatic metastasis, above all, is recognized as an early adverse event in progression of pancreatic cancer and has been described to be an independent poor prognostic fact...

2017
Tao Pu Liqin Xiong Qiyu Liu Minxing Zhang Qingqing Cai Haiou Liu Anil K. Sood Guiling Li Yu Kang Congjian Xu

Lymph node metastasis occurs in early-stage and late-stage ovarian cancers. Systematic lymphadenectomy is frequently conducted in an attempt to prevent disease progression. However, this method is associated with multiple complications. Therefore, it is necessary to develop a less invasive and more sensitive method for detecting lymphatic metastasis in ovarian cancer. The aim of the present stu...

Journal: :Annals of the New York Academy of Sciences 2008
Marc G Achen Steven A Stacker

The metastatic spread of tumor cells is the most lethal aspect of cancer and often occurs via the lymphatic vasculature. Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis. Changes in the adhesive properties of lymphatic endothelium near tumors may also fac...

Journal: :Oncology reports 2016
Weipeng Zhao Jun Wang Bo Zhu Yuzhong Duan Fanglin Chen Weiqi Nian Jianguo Sun Bicheng Zhang Zhongsheng Tong Zhengtang Chen

Lymphangiogenesis is not only involved in the processes of embryonic development, tissue repair and chronic inflammation, but also in tumor lymphatic metastasis. Metastatic tumor cells spreading through lymphatic vessels occur in non-small cell lung carcinoma (NSCLC), with regional lymph node metastasis often being the most important prognostic factor for carcinoma patients. Recent research has...

Journal: :Carcinogenesis 2006
Ramin Shayan Marc G Achen Steven A Stacker

Distant organ metastasis is the most important factor in determining patient survival in cancer. This is thought to occur via the body's own systems for transporting fluid and cells, the blood vascular and lymphatic systems. Cancer cells may exploit these vascular systems by expressing growth factors, which alter the normal pattern of angiogenesis and lymphatic vessel growth (lymphangiogenesis)...

2011
Irena Jankovic Predrag Kovacevic Milan Visnjic Dimitrije Jankovic Ivana Binic Aleksandar Jankovic Ivan Ilic

Basosquamous carcinoma of the skin is a relatively rare cutaneous neoplasm that has significant metastatic potential and a metastatic rate greater than that of basal cell and squamous cell carcinoma. We describe the use of lymphatic mapping and sentinel lymph node biopsy in a 63-year-old man after identification of basosquamous carcinoma. Sentinel lymph node biopsy, which is a standard tool to ...

Journal: :archives of breast cancer 0
a. ali assarian department of surgery, tehran university of medical sciences, tehran, iran ahmad elahi department of surgery, tehran university of medical sciences, tehran, iran

background: contralateral axillary metastasis (cam) is a rare entity in patients with breast cancer which can occur during the primary breast cancer or its follow-up. different treatment modalities include surgery, radiotherapy, and chemotherapy, but there is no agreement on them. in our review, we found 12 series with available data, 82 patients with synchronous or metachronous contralateral a...

2009
Viviane Mumprecht Michael Detmar

Metastasis is a characteristic trait of most tumour types and the cause for the majority of cancer deaths. Many tumour types, including melanoma and breast and prostate cancers, first metastasize via lymphatic vessels to their regional lymph nodes. Although the connection between lymph node metastases and shorter survival times of patients was made decades ago, the active involvement of the lym...

Journal: :Molecular cancer therapeutics 2008
Timothy P Padera Angera H Kuo Tohru Hoshida Shan Liao Jennifer Lobo Kevin R Kozak Dai Fukumura Rakesh K Jain

Blood vessels are required for a tumor to grow and functional lymphatic vessels are required for it to disseminate to lymph nodes. In an attempt to eradicate both the primary tumor and its lymphatic metastasis, we targeted both blood and lymphatic vessels using two different tyrosine kinase inhibitors (TKIs): cediranib and vandetanib, which block vascular endothelial growth factor receptor (VEG...

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