BACKGROUND Interleukin (IL)-2 plays a central role in T cell-dependent immune responses. OBJECTIVES We conducted this study to determine and compare IL-2 expression in lupoid and usual types of Old World Cutaneous Leishmaniasis (OWCL), using immunohistochemistry. PATIENTS AND METHODS Thirteen paraffin-embedded specimens of lupoid and 12 specimens of usual types of OWCL were used. A mouse mo...

Lupoid leishmaniasis is an unusual complication of acute cutaneous leishmaniasis which can represent a diagnostic and therapeutic challenge. The disease is actually a reactivation of an earlier acute cutaneous infection. It usually starts close to or in the scar of previous lesion and can cause severe destruction. Its diagnosis is complicated by the sparsity of the microorganisms in the d...

Background: It appears that chronic lupoid leishmaniasis is the result of type 2 predominant T helper response to parasite and a defect in the down regulation of IL-4 production during infection. The objective of this study was to evaluate the underlying immune status in these patients and their predominant T helper activity we considered serum IgE as an indicator of TH2 activity and IL-4...

OBJECTIVE(S) One of the different types of skin leishmaniasis is the Chronic Lupoid Leishmaniasis (CLL), which is caused by abnormal immune response. On the other hand, HTLV-I has been known to exist in some infectious diseases. Human T cell lymphotropic virus type1 (HTLV-I) and cutanous leishmaniasis exists endemically in Mashhad. The objective of this study was to evaluate the prevalence of H...

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Introduction / objectives Lupoid leishmaniasis (LCL) is a rare, face disfiguring, treatment resistant complication which has responded to the expensive photodynamic therapy in 5 patients in Iran [ F. Ghaffarifar et al. La Rev. de la Méditerranée orientale Vol. 12 No. 6, 2006]. Here we report 5 cases,photodocumented as best as we could under the actually disastrous conditions of Afghan Health Ca...

Background & Objective: There is a complicated interaction between leishmaniasis and the host immune cells, and also between the host immune cells. These interactions have fundamental effects on the outcome of the disease. The current study aimed at characterizing the number, distribution, co-localization, and interrelation of 4 types of inflamma...

Background: Chronic lupoid leishmaniasis (CLL) is a chronicform of cutaneous leishmaniasis that is usually resistant to antileishmania agents and leishmania is not seen in the histologicsections. We used polymerase chain reaction (PCR) to detectleishmania DNA in CLL specimens.Method: This descriptive cross sectional study was done on20 paraffin embedded specimens of CLL cases referred to theder...