نتایج جستجو برای: lung delivery

تعداد نتایج: 508290  

Journal: :Respiratory care 2015
Ariel Berlinski J Randy Willis

BACKGROUND Optimization of factors affecting aerosol delivery during mechanical ventilation in the pediatric population is important. We hypothesized that increasing the tidal volume (V(T)), using a vibrating mesh nebulizer, and placing the nebulizer at the ventilator would increase lung dose/delivery efficiency. METHODS Continuous-output jet and vibrating mesh nebulizers loaded with albutero...

2015
Abdul Waheed Ankit Gupta Parth Patel

In the present scenario, lung cancer is one of the most prevalent and malignant cancer especially among the smoking group of people. The targeted delivery of chemotherapeutic agents to the lungs represents a novel therapeutic approach in lung cancer. Lung is an ideal route for administration of anticancer drug as it provides larger alveolar surface area, low thickness of epithelial barrier & ex...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Ho-Young Lee Young-Ah Suh Janet I Lee Khaled A Hassan Li Mao Thomas Force Brian E Gilbert Tyler Jacks Jonathan M Kurie

PURPOSE Transfer of growth-suppressive genes to lung tumors has therapeutic potential, but effective delivery techniques have not been developed. Here, we investigated gene delivery to lung tumors by aerosolization of adenoviral vectors incorporated into calcium phosphate precipitates. EXPERIMENTAL DESIGN To investigate the efficacy of this delivery method in normal and neoplastic lung, an ad...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2011
William M Gwinn Mayanga C Kapita Ping M Wang Mark F Cesta William J Martin

Idiopathic pulmonary fibrosis is a devastating disease characterized by a progressive, irreversible, and ultimately lethal form of lung fibrosis. Except for lung transplantation, no effective treatment options currently exist. The bleomycin animal model is one of the best studied models of lung injury and fibrosis. A previous study using mouse tumor models observed that liposome-encapsulated bl...

2018
Kenny Schlosser Mohamad Taha Duncan J. Stewart

There is considerable interest in the use of synthetic miRNA mimics (or inhibitors) as potential therapeutic agents in pulmonary vascular disease; however, the optimal delivery method to achieve high efficiency, selective lung targeting has not been determined. Here, we sought to investigate the relative merits of different lung-targeted strategies for delivering miRNA mimics in rats. Methods: ...

2014
Leonie Rudofsky Eleanor Aynsley Sebastian Beck Kai Schubert Gregor Habl Sonja Krause Jürgen Debus Florian Sterzing

The purpose of the study was to evaluate the time effectiveness and dose distribution details of dynamic jaw delivery compared to the regular helical tomotherapy delivery mode in stereotactic body radiation therapy (SBRT) of liver and lung tumors. Ten patients with liver and ten patients with lung tumors were chosen to analyze the dose profiles and treatment times of regular helical tomotherapy...

2016
Ji Young Yhee Jintaek Im Richard Seonghun Nho

Chronic lung diseases include a variety of obstinate and fatal diseases, including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), idiopathic pulmonary fibrosis (IPF), and lung cancers. Pharmacotherapy is important for the treatment of chronic lung diseases, and current progress in nanoparticles offers great potential as an advanced strategy for drug delivery. Based ...

Journal: :American journal of biomedical science & research 2021

The COVID19 virus also affects pregnant women. While the vast majority of infected patients have few symptoms, about 10% them may a pneumonia that is important to diagnose and treat. Initial data from literature suggest management similar general population. There greater risk premature delivery requiring administration corticosteroids for fetal lung maturation in event imminent delivery.

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