This study of spinal cord injury in bullfrog (Rana catesbeiana) tadpoles using the neuroanatomical tracer horseradish peroxidase (HRP) was undertaken to determine (1) whether the same anatomical regions that normally give rise to ascending or descending spinal tracts do so following complete spinal cord transection and (2) whether the course of behavioral recovery could be related to the anatom...

BACKGROUND Amylin and Salmon Calcitonin belong to the calcitonin family of peptides and have high affinity binding sites in the rat spinal cord. The aim of this study was to characterize receptors for Amylin and Salmon Calcitonin functionally in the spinal cord of rats. We assessed the expression of c-Fos in response to intraplantar formalin in the lumbar regions of the spinal cord in conscious...

clear cell variant of ependymoma is almost exclusively located in the supratentorial region. only few cases of this tumor that located in the spinal cord have been reported. here we report one case of intramedullary clear cell ependymoma of the lumbar spinal cord. in microscopic examination, the tumor cells were round to oval with moderate amounts of clear cytoplasm and centrally located large ...

BACKGROUND Spinal cord compression is a known cause of spinal cord injury. The purpose of this study is to measure pressure response during graded spinal cord compression. This information will be important in evaluating the amount of canal compromise that can be tolerated before risking neurological injury secondary to cord compression. To date, there is no published study that has evaluated p...

Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig myelin basic protein (MBP) and Freund's adjuvant. The histological studies showed demyelination in the lumbar, sacral and coccygeal dorsal and ventral spinal roots and to a lesser extent in the spinal cord, including the dorsa...

Introduction: Foetal spinal cord has been the focus of interest by many scientists but the information regarding lumbar enlargement received very little attention, though important for clinical applications. Morphological studies were limited to vertebral canal and spinal cord during prenatal and postnatal periods . Readings of maximum transverse diameter of lumbar enlargement of foetal spinal ...

Neural precursor cells (NPCs) are promising grafts for treatment of traumatic CNS injury and neurodegenerative disorders because of their potential to differentiate into neurons and glial cells. When designing clinical protocols for NPC transplantation, it is important to develop alternatives to direct parenchymal injection, particularly at the injury site. We reasoned that since it is minimall...

After spinal cord transection, the generation of stepping depends on neurotransmitter systems entirely contained within the local lumbar spinal cord. Glutamate and glycine likely play important roles, but surprisingly little is known about how the content of these two key neurotransmitters changes to achieve weight-bearing stepping after spinal cord injury. We studied the levels of glutamate an...

The aim of this study was to anatomically verify echo-guided identification of key lumbar arteries supplying blood to the spinal cord and to examine whether changes in nerve root motion could be used for detecting malperfusion following aortic cross-clamping. In two beagle dogs, nerve root motion was monitored through the intervertebral disc using transesophageal echocardiography. Communication...

Networks generating locomotor-like rhythmic motor activity are formed during the last week of the fetal period in the rat spinal cord. We investigated the coordinated rhythmic motor activity induced in transverse slice preparations of the lumbar spinal cord taken from fetal rats as early as embryonic day (E) 16.5. In slices as thin as 100 microm, bath-application of 5-hydroxytryptamine (5-HT) i...