نتایج جستجو برای: ltb

تعداد نتایج: 643  

2017
Nathella Pavan Kumar Kadar Moideen Chandrakumar Dolla Paul Kumaran Subash Babu

Type 2 diabetes mellitus (DM) is associated with the down modulation of Th1, Th2 and Th17 responses in latent Mycobacterium tuberculosis infection but the role of prediabetes (PDM) in this setting is not well understood. To examine the role of CD4+ and CD8+ T cell cytokines in latent tuberculosis (LTB) with coincident PDM, we studied the baseline, mycobacterial, control antigen and mitogen-stim...

Journal: :Journal of immunology 2003
Chang-Hoon Woo Min-Hyuk Yoo Hye-Jin You Sung-Hoon Cho Yeung-Chul Mun Chu-Myong Seong Jae-Hong Kim

The epithelial cells that form a barrier lining the lung airway are key regulators of neutrophil trafficking into the airway lumen in a variety of lung inflammatory diseases. Although the lipid mediator leukotriene B(4) (LTB(4)) is known to be a principal chemoattractant for recruiting neutrophils to inflamed sites across the airway epithelium, the precise signaling mechanism involved remains l...

Journal: :Infection and immunity 2010
Peter Mancuso Casey Lewis Carlos Henrique Serezani Deepti Goel Marc Peters-Golden

Leukotriene B(4) (LTB(4)) is a potent lipid mediator of inflammation formed by the 5-lipoxygenase (5-LO)-catalyzed oxidation of arachidonic acid. We have previously shown that (i) LTB(4) is generated during infection, (ii) its biosynthesis is essential for optimal antimicrobial host defense, (iii) LT deficiency is associated with clinical states of immunocompromise, and (iv) exogenous LTB(4) au...

Journal: :Journal of immunology 2012
C Henrique Serezani Steve Kane Latima Collins Mariana Morato-Marques John J Osterholzer Marc Peters-Golden

Pattern recognition receptors for fungi include dectin-1 and mannose receptor, and these mediate phagocytosis, as well as production of cytokines, reactive oxygen species, and the lipid mediator leukotriene B(4) (LTB(4)). The influence of G protein-coupled receptor ligands such as LTB(4) on fungal pattern recognition receptor expression is unknown. In this study, we investigated the role of LTB...

Journal: :The Journal of Experimental Medicine 2000
Takehiko Yokomizo Kazuhiko Kato Kan Terawaki Takashi Izumi Takao Shimizu

Leukotriene B(4) (LTB(4)) is a potent chemoattractant and activator of both granulocytes and macrophages. The actions of LTB(4) appear to be mediated by a specific G protein-coupled receptor (GPCR) BLT1, originally termed BLT (Yokomizo, T., T. Izumi, K. Chang, Y. Takuwa, and T. Shimizu. 1997. Nature. 387:620-624). Here, we report the molecular cloning of a novel GPCR for LTB(4), designated BLT2...

Journal: :Journal of immunology 2011
Ana Paula T Monteiro Carla S Pinheiro Tatiana Luna-Gomes Liliane R Alves Clarissa M Maya-Monteiro Barbara N Porto Christina Barja-Fidalgo Claudia F Benjamim Marc Peters-Golden Christianne Bandeira-Melo Marcelo T Bozza Claudio Canetti

High concentrations of free heme found during hemolytic events or cell damage leads to inflammation, characterized by neutrophil recruitment and production of reactive oxygen species, through mechanisms not yet elucidated. In this study, we provide evidence that heme-induced neutrophilic inflammation depends on endogenous activity of the macrophage-derived lipid mediator leukotriene B(4) (LTB(4...

Journal: :Experimental parasitology 2006
Claudia Machuca Adriana Rodríguez Marymar Herrera Sonia Silva Alicia Ponte-Sucre

We compared growth rate, cell glucose turnover and expression of ATP-binding-cassette (ABC) transporters in Leishmania amazonensis (LTB0016; LTB) versus LTB(160) selected for resistance against the ABC transporter blocker glibenclamide. Additionally, we evaluated the influence of drug-resistance on Leishmania sensitivity against 2-mercaptoacetate and 2-deoxyglucose. Our data demonstrate that (1...

2000
Takehiko Yokomizo Kazuhiko Kato Kan Terawaki Takashi Izumi Takao Shimizu

Leukotriene B 4 (LTB 4 ) is a potent chemoattractant and activator of both granulocytes and macrophages. The actions of LTB 4 appear to be mediated by a specific G protein–coupled receptor (GPCR) BLT1, originally termed BLT (Yokomizo, T., T. Izumi, K. Chang, Y. Takuwa, and T. Shimizu. 1997. Nature. 387:620–624). Here, we report the molecular cloning of a novel GPCR for LTB 4 , designated BLT2, ...

2015
Ho Seob Soh Ha Young Chung Hyun Ho Lee Hemavathi Ajjappala Kyoungok Jang Jong-Hwa Park Joon-Soo Sim Gee Young Lee Hyun Ju Lee Young Hee Han Jae Wook Lim Inchan Choi In Sik Chung Bum-Soo Hahn

We expressed the heat-labile enterotoxin B (LTB) subunit from enterotoxigenic Escherichia coli and the cholera toxin B (CTB) subunit from Vibrio cholerae under the control of the rice (Oryza sativa) globulin (Glb) promoter. Binding of recombinant LTB and CTB proteins was confirmed based on GM1-ganglioside binding enzyme-linked immunosorbent assays (GM1-ELISA). Real-time PCR of three generations...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Juan J Moreno

The beneficial effects of fish oil on inflammation have been attributed to the content of eicosapentaenoic (EPA)/docosahexaenoic acid. EPA is also a substrate for arachidonic acid (AA) cascade enzymes, but it induces the production of alternative eicosanoids such as 3-series prostanoids and 5-series leukotrienes, which are considered to be less proinflammatory than AA metabolites. However, the ...

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