BACKGROUND although proactive primary care, including early detection and treatment of community-dwelling frail older people, is a part of the national healthcare policy in several countries, little is known about its cost-effectiveness. OBJECTIVE to evaluate the cost-effectiveness of a proactive primary care approach in community-dwelling frail older people. DESIGN AND SETTING embedded in ...

BACKGROUND Access to HIV-1 voluntary counselling and testing (VCT) is severely limited in less-developed countries. We undertook a multisite trial of HIV-1 VCT to assess its impact, cost, and cost-effectiveness in less-developed country settings. METHODS The cost-effectiveness of HIV-1 VCT was estimated for a hypothetical cohort of 10000 people seeking VCT in urban east Africa. Outcomes were ...

BACKGROUND While there is scientific evidence to support the efficacy of preventive interventions for pressure ulcers, few empirical data are available on their cost-effectiveness. The aim of this study was to determine the cost-effectiveness of interventions to prevent pressure ulcers. METHODS Cost of preventive interventions and days of ulcer-free survival were compared for two groups of pa...

background: this study aims to investigate the patterns of bioaccumulation and depuration of copper in the selected kidney and liver of capoeta fusca. methods: the fish were collected between september and november 2010 from a qanat in birjand. they were exposed to two types treatments with copper (0.25 and 0.75 mg/l) for a period of 41 days. the fish under study were exposed to the above-menti...

objective: successful bonding of a dental implant to bone, which was referred to as osseointegration by branemark has been well documented. however, long-term prognosis of an implant depends on adequate maintenance and long-term care. an effective maintenance program is required to preserve the health of peri-implant tissues. several techniques have been suggested for this purpose but it is not...

conclusions the stereotactic brachytherapy for patients with circumscribed and relatively small size tumors appears to be a safe, feasible, and minimally-invasive treatment. results thirteen patients were male and 16 were female, with the median age of 29 years (range, 2.5 – 64 years). the median follow-up was 95 (range, 6 – 240) months. based on pignatti classification, 10 patients were at low...

introduction: stress is associated with neurological and cognitive disorders. it has been suggested that doxepin, in addition to its influence on the content of neurotransmitters, has probable neuroprotective effects as well. therefore, the aim of this study was to investigate the effects of doxepin on synaptic plasticity and brain-derived neurotrophic factor (bdnf) gene expression in the rat h...

long-term potentiation (ltp) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. the first clue of the potential role of glutamate receptors in ltp was in 1991 with the observation that the mglur agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (acpd), increased ltp. studies have shown that acpd induc...