BACKGROUND Platinum-based neoadjuvant chemotherapy (NAC) is new therapeutic strategy for locally advanced cervical carcinoma, but the variables used to predict NAC response are still infrequently reported. The aim of our study was to investigate the association between XRCC1 gene single nucleotide polymorphisms (SNPs) and NAC response. METHODS Seventy patients with locally advanced cervical c...

As compared to other cancers, the incidence of cervical carcinoma is relatively high (Arbyn et al., 2011). Certain human papillomavirus (HPV) types are carcinogenic in humans, and more than 99% of cervical cancers are associated with HPV infection. Genital HPV types are divided into high-, medium-, and low-risk groups based on the frequency of association with malignant tumors (Monsonego et al....

The mechanism by which overexpression of hexokinase 2 (HK2) indicates locally advanced cervical squamous cell carcinoma (LACSCC) with radio-resistance is still unknown despite being an independent biomarker of poor prognosis. Here, we retrospectively analyzed 132 female patients receiving radiotherapy for cervical squamous cell carcinoma including 85 radiation-sensitive cases and 47 radiation-r...

Radiotherapy is the primary form of treatment in patients with locally advanced cervical carcinoma. However for residual disease in the form of the persistent lymph nodes, surgery or chemotherapy is recommended. As surgery is not acceptable by every patient and chemotherapy has associated side effects, we hereby report the positive outcome of in vitro expanded natural killer cell and activated ...

INTRODUCTION Adenoid cystic carcinoma is a malignant epithelial neoplasm derived from the salivary glands. Primary adenoid cystic carcinoma of the cervix is extremely rare, accounting for less than 1% of all cervical carcinomas. In this paper we report a case of primary adenoid cystic carcinoma and a review of the related literature. CASE PRESENTATION A 68 year-old woman was admitted with sig...

abstract: primary adenoid cystic carcinoma (acc) of bartholin’s gland is a rare gynecologic malignancy. we report a case of locally advanced acc of bartholin’s gland. a 62-year-old presented with left bartholin’s gland carcinoma and underwent left radical vulvectomy,left-sided inguinal-femoral lymph node dissection, posterior pelvic exenteration, and pedicle abdominal muscle flap. on her 3 mont...

background & objective:the present study was undertaken to ascertain the incidence of early, advanced cancer cervix and its recurrence and role of chemotherapy in locally advanced cancer cervix. material and methods: the present study was conducted in the departments of obstetrics & gynaecology, pathology and radiotherapy and the specimens examined in the department of pathology of jaw...

BACKGROUND Sentinel lymph node (SN) biopsy based on dual labeling with blue dye and radiocolloid can reliably determine lymph node status in early-stage cervical cancer, but few data are available on its accuracy in more advanced disease. We examined the influence of tumor stage on the accuracy of SN biopsy in patients with cervical cancer. METHODS Between July 2001 and June 2004, 33 patients...