BACKGROUND The optimum treatment for high-risk soft-tissue sarcoma (STS) in adults is unclear. Regional hyperthermia concentrates the action of chemotherapy within the heated tumour region. Phase 2 studies have shown that chemotherapy with regional hyperthermia improves local control compared with chemotherapy alone. We designed a parallel-group randomised controlled trial to assess the safety ...

The value of hyperthermia as an adjuvant to radiotherapy in patients with malignant melanoma was studied in a European multicentre trial. 134 metastatic or recurrent lesions of malignant melanoma in 70 patients were randomly assigned to receive radiotherapy (three fractions of 8 Gy or 9 Gy in 8 days) alone or followed by hyperthermia (43 degrees C for 60 min). Overall, the 2-year actuarial loca...

Introduction Cisplatin is one of the standard treatments head and neck tumors leading frequently to severe systemic side effects. This could be improved by targeted drug delivery with nanoparticles in combination local hyperthermia. Unfortunately, outcome studies on hyperthermia HNSCC are diverse. Therefore, we started testing effect nanoparticle uptake HNSCC-cell lines, their toxicity,

The heating of deep visceral tumors with implanted electrodes and with self-regulating ferromagnetic thermoseeds was inves tigated. Clinical trials on six patients heated with implanted electrodes indicate that good local tumor control can be obtained by application of hyperthermia during a normal course of radio therapy. The heating method was found practical, and neither toxicity nor severe p...

In oncology, the term 'hyperthermia' refers to the treatment of malignant diseases by administering heat in various ways. Hyperthermia is usually applied as an adjunct to an already established treatment modality (especially radiotherapy and chemotherapy), where tumor temperatures in the range of 40-43 degrees C are aspired. In several clinical phase-III trials, an improvement of both local con...

In tissue culture, the cytotoxicity of a number of commonly used chemotherapeutic drugs is greatly enhanced at elevated temperatures. However, pharmacokinetics, drug concentra tions, oxygen tension, and pH in tumors in animals can all vary widely from those in cell cultures. In addition, tissue culture studies do not give vital information on the effect of combina tions of drugs and hyperthermi...

Abstract Local tumour hyperthermia for cancer treatment is currently used either for ablation purposes as an alternative to surgery or less frequently, in combination with chemotherapy and/or radiation therapy to enhance the effects of those traditional therapies. As it has become apparent that activating the immune system is crucial to successfully treat metastatic cancer, the potential of boo...

PURPOSE To develop and validate a computational model that simulates (1) tissue heating with high intensity focused ultrasound (HIFU), and (2) resulting hyperthermia-mediated drug delivery from temperature-sensitive liposomes (TSL). MATERIALS AND METHODS HIFU heating in tissue was simulated using a heat transfer model based on the bioheat equation, including heat-induced cessation of perfusio...