The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although findings are contradictory. Efficiency of ILE was demonstrated in animal studies in the treatment of sev...

the intraoperative care of pheochromocytomas can be difficult and lead to serious complications. we present a case of a 46 year-old female undergoing laparoscopic resection of pheochromocytoma, who was scheduled for surgery with phenoxybenzamine and amlodipin. under general anesthesia cardiovascular stability was achieved by peritumoral infiltration of lidocaine during resection.

background: severe abdominal pain is not common after laparoscopic surgeries, but acute or chronic pain after operation is considerable in some patients. post-operative pain control after laparoscopic surgeries, is conventionally achieved using analgesics such as non-steroidal anti-inflammatory drugs (nsaids) and narcotics, but their administration has a lot of side effects. this study compares...

BACKGROUND The use of intravenous lipid emulsion (ILE) therapy for the treatment of lipophilic drug toxicity is increasing. Despite this, the evidence for its effect in non-local anesthetic toxicity remains sparse. Furthermore, many case reports describe ILE use for substances in which no clear efficacy data exists. The American Academy of Clinical Toxicology established a lipid emulsion workgr...

One of the very real complications possible in the use of local anesthetic agents is a relative overdose of the drug, resulting in an inordinate and potentially dangerous serum level. Even when using strict and careful technique, problems can occur. The reactions cited in the aforementioned cases were most likely the result of the accidental intravenous injection of a local anesthetic agent. Tw...

Background: Our aim was to evaluate the effect of intravenous intralipid administration as an antidote on the poisoned patients' Glasgow Coma Scale (GCS), hemodynamic parameters, arterial blood gas analysis, and routine metabolic profile tests (i.e. urea, glucose, sodium, and potassium) in the setting of non-local anesthetic drug overdose. Methods: In this randomized controlled trial, a total o...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

The accidental overdose of local anesthetics may prove fatal. The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death. Local anesthetics are the most frequently used drugs amongst anesthetists and although uncommon, local anaesthetic systemic toxicity accounts for a high proportion of mortality, with lo...

conclusions cooling the injection site prior to local anesthetic injection is an effective and inexpensive method to reduce the pain and discomfort caused by the injection. methods subjects who presented with superficial lacerations were randomly assigned to 2 groups, the first group received ice packing prior to injection and the second did not. the pain severity, length and depth of the lacer...