In recent times, the role(s) of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in the pathogenesis of various cancers has received great attention. Indeed, there is also a growing recognition of regulatory RNA cross-talk, i.e., lncRNA-miRNA interactions, that may modulate various events in carcinogenesis and progression to metastasis. This review summarizes current evidence in the literat...

Abstract Objectives Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related deaths, due to high morbidity, a low early diagnosis rate, and poor prognosis. It essential explore competitive endogenous RNA (ceRNA) arrays for prognosis HCC. Methods The original gene expression profiles differentially expressed lncRNA, miRNA mRNA in HCC were downloaded from TCGA database. Diff...

Emerging evidence shows that dysregulated expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) were closely linked with disease progression, including cancers. However, the joint predictive power of miRNAs and lncRNAs in prognosis for ovarian cancer (OV) patients with wild-type BRCA1/2 is as yet unknown. In this study, we sought to assess the joint predictive power of miRNAs and ...

Abstract Background Competitive endogenous RNA (ceRNA) networks have revealed a new mechanism of interaction between RNAs, and play crucial roles in multiple biological processes development neoplasms. They might serve as diagnostic prognosis markers well therapeutic targets. Methods In this work, we identified differentially expressed mRNAs (DEGs), lncRNAs (DELs) miRNAs (DEMs) sarcomas by comp...

Hepatocellular carcinoma (HCC) is one of the most common cancers and main cause cancer-related death globally. Immune dysregulation CD4+ T cells has been identified to play a role in development HCC. Nevertheless, underlying molecular pathways HCC are not completely known. Thus, better understanding lncRNA-miRNA/mRNA network may yield novel insights into etiology or progression In this study, c...

Background: Primary Sjögren’s syndrome (pSS) is a relatively common autoimmune disease characterized by oral and ocular dryness. An increasing number of studies have revealed that long non-coding RNA (lncRNA), miRNA, mRNA circular (circRNA) contributes to the pathogenesis diseases. Objectives: To explore lncRNA, circRNA expression profiles in labial salivary glands (LSGs) pSS patients their bio...

The epithelial cell adhesion molecule (EpCAM) is highly expressed in the liver during development and diseases. However, its role pathology of remains to be explored. tissues EpCAM-/- wildtype (WT) mice at P0 stage were used for RNA sequencing. differently miRNAs, lncRNAs mRNAs selected confirmed by qPCR. expression metabolism-related gene SET domain bifurcated 2 (Setdb2) was significantly incr...

Recently, the attention of the research community has been focused on long non-coding RNAs (lncRNAs) and their physiological/pathological implications. As the number of experiments increase in a rapid rate and transcriptional units are better annotated, databases indexing lncRNA properties and function gradually become essential tools to this process. Aim of DIANA-LncBase (www.microrna.gr/LncBa...

The identification of deregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In addition, the cross-regulation between lncRNAs and miRNAs has begun to emerge, and theoretical and experimental studies have demonstrated the competing endogenous RNA (ceRNA) activity of lncRNAs as natural miRNA ...

Background: Non-small-cell lung carcinoma (NSCLC) is the most common type of lung cancer with poor prognosis despite advent of newer treatment modalities. The role of long non-coding RNA (lncRNA)-Xist in cancer including NSCLC has already been established. Hence, understanding the underlying mechanism of action of lncRNA-Xist in NSCLC might provide basis for novel drug targets. Objective: In th...