Signal relay by guidance receptors at the axonal growth cone is a process essential for the assembly of a functional nervous system. We investigated the in vivo function of Src family kinases (SFKs) as growth cone guidance signaling intermediates in the context of spinal lateral motor column (LMC) motor axon projection toward the ventral or dorsal limb mesenchyme. Using in situ mRNA detection w...

This paper presents the main characteristics of Logic Models Creator (LMC). LMC is a new educational environment for young students to build and explore logic models in graphical form. LMC allows visual representation of logic models using IF/THEN/ELSE constructs. In this paper we provide an overview of LMC architecture and discuss briefly an example of use of LMC. As discussed, LMC users in th...

The recently reported microlensing events of the LMC have caused much excitement, and have been interpreted as due to ‘dark objects’ (MACHOs) in the halo of our Galaxy. It is shown here that the stars within the LMC play a dominant role as gravitational lenses and can indeed account for the observed events. For observations within the bar of the LMC, the probability of microlensing being caused...

Based on an analysis of the interstellar highly ionised species C IV, Si IV, N V, and O VI observed in the FUSE and HST/STIS E140M spectra of four hot stars in the Large Magellanic Cloud (LMC), we find evidence for a hot LMC halo fed by energetic outflows from the LMC disk and even possibly an LMC galactic wind. Signatures for such outflows are the intermediate and high-velocity components (vLS...

We observed seven central stars of planetary nebulae (CSPN) in the Large Magellanic Cloud (LMC) with the Far Ultraviolet Spectroscopic Explorer (FUSE), and performed a model-based analysis of these spectra in conjunction with Hubble Space Telescope (HST) spectra in the UV and optical range to determine the stellar and nebular parameters. Most of the objects show wind features, and they have eff...

We first show that a large amount of metal-poor gas is stripped from the Small Magellanic Cloud (SMC) and fallen into the Large Magellanic Cloud (LMC) during the tidal interaction between the SMC, the LMC, and the Galaxy over the last 2 Gyrs. We propose that this metal-poor gas can closely be associated with the origin of LMC’s young and intermediate-age stars and star clusters with distinctive...

The nature of Large Magellanic Cloud (LMC) microlensing is determined by the location of the microlensing source stars. If the source stars are in the LMC then LMC microlensing is predominantly halo-lensing, if the source stars are located behind the LMC, then LMC microlensing is dominated by self-lensing. We attempt to distinguish between source stars drawn from the average population of the L...

Leptomeningeal carcinomatosis (LMC) is the multifocal seeding of cerebrospinal fluid and leptomeninges by malignant cells. The incidence of LMC is approximately 5% in patients with malignant tumors overall and the rate is increasing due to increasing survival time of cancer patients. Eradication of the disease is not yet possible, so the treatment goals of LMC are to improve neurologic symptoms...

Theory predicts that local mate competition (LMC) favors the evolution of female-biased sex ratios. Empirical support of this prediction is indirect and comes from comparative studies or from studies showing that individuals can adjust their offspring sex ratio in response to varying LMC intensities. Replicate lines from a population of the spider mite Tetranychus urticae were selected under th...

A critical step in the assembly of the neural circuits that control tetrapod locomotion is the specification of the lateral motor column (LMC), a diverse motor neuron population targeting limb musculature. Hox6 paralog group genes have been implicated as key determinants of LMC fate at forelimb levels of the spinal cord, through their ability to promote expression of the LMC-restricted genes Fo...