these experiments examined the effects of pre-test intra dorsal hippocampus (intra-ca1) administration of gabaa receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. male nmri mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received ip injections of either saline (10 ml/kg...

objective(s) it is believed that the mesenchymal stem cell (msc) differentiation and proliferation are the results of activation of wnt signaling pathway. on the other hand, lithium chloride is reported to be able to activate this pathway. the objective of this study was to investigate the effect of lithium on in vitro proliferation and bone differentiation of marrow-derived msc. materials and ...

objective: the influence of cholinergic drugs on lithium-induced statedependent learning has been investigated in adult male mice. method: a single-trial step-down inhibitory avoidance task was selected. the drugs used in the study were lithium chloride physostigmine , nicotine hydrogen tartrate and scopolamine hydrobromide, atropine sulphate. the drugs were administrated through the peritoneal...

the effect of neuroloptics. carbamacepine and hensmliacepines in treatment of 8.3 patients with acute mania was studied. according to drug types. patients were divided into 5 groups: 1) lithium combined with ilubupridol. 2) lithium combined with one plxenoshiacine 3) lithium combined with two phenothiazines. 4) lithium combined with cubumazepine and 5) lithium combined with benzxliazepines no s...

in the present study, the interactions of three different lithium species li+, li3+ and ch3li with several different sites of the most stable tautomers of dna nucleo-bases are presented. this investigation is based on the results of thermochemical properties, quantum theory of atoms in molecules (qtaim) and natural bond orbital (nbo) analysis, obtained at b3lyp/6-311++g(d,p) level of theory. th...

These experiments examined the effects of pre-test intra dorsal hippocampus (intra-CA1) administration of GABAA receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. Male NMRI mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received IP injections of either saline (10 mL/kg...

background: b cell cll/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium’s neuroprotective effect. however, most studies have focused on assessing the effects of lithium in neurons, ignoring examination of bcl-2 in astrocytes, which also influence neuronal survival and are affected in bipolar disorder. the aim of this study was to evaluate whet...

Background and Objectives: Previous studies have indicated that lithium may increase the level of the brain-derived neurotrophic factor (BDNF), which in turn improves the recovery of patients with stroke. In this controlled trial we evaluated the effect of lithium on BDNF serum level in patients with ischemic stroke. Methods: In this randomized controlled...

  The effects of gentamicin, lithium and combination of these drugs on ultrastructural morphology of rat submandibular glands were studied. Daily intraperitoneal injection of 40 mg/kg of gentamicin which causes chronic salivary gland toxicity, led to a marked decrease in gland's dry weight and total protein concentration but did not affect DNA content. Electron micrograph (EM) of submandibular ...

Lithium is an element which has been used as salts of chloride or carbonate for many years in the treatment of some psychological disorders such as mania, bipolar or schizophrenic diseases. Chronic application of lithium may induce some serious nephropathies such as natriuresis, renal tubular acidosis, tubulointerstitial nephritis progression to progressive chronic kidney disease and hypercalce...