Introduction: The mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. The effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. To further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14C] clozapine with suita...

This article describes CLEAN, an approach to the detection of low-energy solar neutrinos and neutrinos released from supernovae. The CLEAN concept is based on the detection of elastic scattering events (neutrino-electron scattering and neutrinonuclear scattering) in liquified noble gases such as liquid helium, liquid neon, and liquid xenon, all of which scintillate brightly in the ultraviolet. ...

An 800 l liquid xenon scintillation γ ray detector is being developed for the MEG experiment which will search for μ → eγ decay at the Paul Scherrer Institut. Absorption of scintillation light of xenon by impurities might possibly limit the performance of such a detector. We used a 100 l prototype with an active volume of 372×372×496 mm to study the scintillation light absorption. We have devel...

A 68 Ge source can be used to calibrate the positron detection eeciency of a liquid scintillation neutrino detector. A method to dissolve radioactive 68 Ge in pseudocumene-based liquid scintillator is described. The homogeneity of the source distribution has been studied and results for two Ge compounds are discussed. Light yield and light attenuation length of the liquid scintillator are not a...

Abstract We present several novel ionization-electron and scintillation-photon recording concepts in noble-liquid detectors, for future applications particle astroparticle physics other fields. These involve both single- dual-phase detector configurations with combined electroluminescence small charge multiplication gas liquid media.

Detailed Monte-Carlo simulations were used to evaluate the performance of a liquid neon scintillation detector for dark matter and low-energy solar neutrino interactions. A maximum-likelihood event vertex fitter including PMT time information was developed, which significantly improves position resolution over spatial-only algorithms, and substantially decreases the required detector size and a...

The XENON experiment aims at the direct detection of dark matter in the form of WIMPs (Weakly Interacting Massive Particles) via their elastic scattering off Xe nuclei. A fiducial mass of 1000 kg, distributed in ten independent liquid xenon time projection chambers(LXeTPCs) will be used to probe the lowest interaction cross section predicted by SUSY models. The TPCs are operated in dual (liquid...

PURPOSE The goal of this research was to design a liquid scintillation dosimeter that could be used forrelative dosimetry of linear accelerator fields. The project emphasized minimization of cost and ease of use. METHODS The scintillator that was used in this research was BETAMAX- ES scintillation cocktail from MPBiomedical. This particular scintillator was selected due to its relatively high...

The ArDM experiment, a 1 ton liquid argon TPC/Calorimeter, is designed for the detection of dark matter particles which can scatter off the spinless argon nuclei. These events producing a recoiling nucleus will be discerned by their light to charge ratio, as well as the time structure of the scintillation light. The experiment is presently under construction and will be commissioned on surface ...