BACKGROUND The increased incidence of fungal resistance has necessitated the need to search for new antifungal agents. OBJECTIVE The main objectives of the present study were to investigate the effectiveness of the essential oil of Eucalyptus camaldulensis on dermatophytes growth and to formulate and characterize a liposomal gel loaded with the essential oil. MATERIALS AND METHODS The essen...

Aim: Formulation of aceclofenac (ACE) into liposomal gel, improving its skin permeation and potentiate its local anti-inflammatory effect. Methodology: ACE liposomes were fabricated by lipid film hydration technique. The prepared formulations were traditional liposomes containing cholesterol (F1), ultra-deformable liposomes containing Tween 60 (F2) and modified liposomes containing both cholest...

       Cyproterone acetate (CA) has been loaded to liposome by solvent evaporation and thin film formation technique. The effects of some formulation variables such as temperature of organic solvent evaporation, rotary evaporator speed, volume of organic solvent, volume of balloon and temperature of hydrating buffer has been evaluated. The data showed that bigger balloon with higher surface are...

BACKGROUND Photodynamic therapy (PDT) is a clinically-accepted approach for the therapy of many types of cancer. This study focused on the treatment of mammarian carcinoma by topical administration of hydroxyl-aluminium phthalocyanine (AlOH-PC), compared to a clinically-approved photosensitizer (Metvix, Galderma & PhotoCure ASA, Inc., Oslo, Norway). MATERIALS AND METHODS MDA-MB 231 cells were...

Objective: The aim of our study was to formulate and evaluate the liposomal carrier system for the local treatment for mixed vaginal infections. The combination of voriconazole and metronidazole were selected as model drugs for mixed vaginal infections.Methods:Multi lamellar liposomescomposed phosphatidylcholine and cholesterol along with combination of drugs was prepared by the thin film hydra...

Cosmeceutical with Active Substances in the Liposomal System Kosmeseutikal merupakan produk kosmetika yang mengandung bahan aktif biologis memiliki manfaat terapeutik pada permukaan diterapkan. Sistem liposom dalam sediaan kosmeseutikal berguna untuk mempermudah penetrasi zat ke kulit, sehingga telah banyak pengembangan formulasi dengan sistem liposom. Sediaan paling umum digunakan bentuk semi ...

The purpose of this work was to develop and characterize a vesicular drug carrier for topical delivery of Quetiapine to overcome the problems related with oral route that is high first pass metabolism and fluctuating drug plasma concentration. The effects of key formulation variables on entrapment efficiency (EE %), vesicle size and in vitro drug permeation were studied using a BoxBehnken desig...

background: sustained release delivery system can reduce the dosage frequency and maintain the therapeutic level of drugs for a longer time. biodegradable, biocompatible and thermosensitive chitosan-beta-glycerophosphate (c-gp) solutions can solidify at body temperature and maintain their physical integrity for a longer duration. objectives: to develop a novel delivery system based on the integ...

As per world health organization (WHO) report in 2020 about 2.3 million were diagnosed globally with breast cancer and around 6.85 lacs death occurs due to cancer. In such case usage of natural anticancer remedies can provide beneficial results, but unfortunately drugs are not being practically useful trifling bioavailability unempirical data effectiveness. current study, liposomal gels formula...