نتایج جستجو برای: lipocalin

تعداد نتایج: 3085  

Journal: :The Egyptian journal of immunology 2011
Behairy El-Sayed Behairy Elsayed Ibrahim Salama Alif Abdel Hakim Allam Mohamed Abd El Hafeez Ali Azza Mohamed Abd Elaziz

Bacterial infections are common in chronic liver disease, and may precipitate other complications, such as encephalopathy and hepatorenal syndrome. The physiologic functions of lipocalin-2 remain poorly understood. Our aim was to elucidate lipocalin-2 as a useful marker of bacterial infections in children with CLD. A total of 79 children were enrolled in the study; 29 CLD with bacterial infecti...

Journal: :journal of comprehensive pediatrics 0
nastaran khosravi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iran hosein karimi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) nasrin khalesi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) rozita hoseini pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) mitra mehrazma pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) niloofar khosravi ali-asghar children hospital, iran university of medical sciences, tehran, ir iran; ali-asghar children hospital, iran university of medical sciences, tehran, ir iran. tel: +98-2144297768سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

conclusions sepsis enhances the production of plasma ngal in critically ill neonates. thus plasma ngal can help clinicians diagnose sepsis in critically ill neonates during early phases. results the ngal levels were significantly higher in septic neonates compared with non-septic neonates (102.9 ± 69.9 ng/ml versus 29.2 ± 13.3 ng/ml, p value = 0.0001). an optimal cut off-point of 48 ng/ml for s...

Journal: :Indian Journal of Pharmaceutical Sciences 2021

To observe the changes of neutrophil gelatinase associated apolipoprotein (neutrophil lipocalin), lipoprotein phospholipase A2 and inflammatory cytokine hypersensitive C-reactive protein in patients with coronary heart disease to explore correlation between serum lipoproteinassociated A2, lipocalin, degree artery disease. 200 inpatients cardiovascular department our hospital were divided into g...

2012
Elisabeth P. Cramer Andreas Glenthøj Mattias Häger Anna Juncker-Jensen Lars H. Engelholm Eric Santoni-Rugiu Leif R. Lund Ole D. Laerum Jack B. Cowland Niels Borregaard

NGAL/lipocalin-2 is a siderophore-binding protein that is highly expressed in several cancers. It is suggested to confer a proliferative advantage to cancer cells. Its expression has been correlated with aggressiveness of breast cancer as determined both in patients and in mouse breast cancer models. This was recently confirmed in two mouse models of spontaneous breast cancer in wild-type and l...

Journal: :iranian journal of basic medical sciences 0
farzaneh sharifipour imam reza hospital, mashhad university of medical sciences, mashhad, iran abbasali zeraati imam reza hospital, mashhad university of medical sciences, mashhad, iran maryam sahebari rheumatic diseases research center (rdrc), mashhad university of medical sciences, mashhad, iran mohammadreza hatef rheumatic diseases research center (rdrc), mashhad university of medical sciences, mashhad, iran masih naghibi imam reza hospital, mashhad university of medical sciences, mashhad, iran zahra rezaieyazdi rheumatic diseases research center (rdrc), mashhad university of medical sciences, mashhad, iran

objective(s): lupus nephritis (ln) is the main cause of mortality and disability in systemic lupus erythematosus (sle) patients. therefore, utilizing a reliable and non-invasive method for serial measurements of renal function seems to be necessary. the aim of this study was to evaluate the role of urinary lipocalin-2 as a biomarker of renal involvement in sle patients.   materials and methods:...

Journal: :Clinical chemistry 2007
Yu Wang Karen S L Lam Edward W Kraegen Gary Sweeney Jialiang Zhang Annette W K Tso Wing-Sun Chow Nelson M S Wat Jian Yu Xu Ruby L C Hoo Aimin Xu

BACKGROUND Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies. METHODS We used real-time PCR and in-house immunoassays to quantify the mRNA and serum concentrations of lipocalin-2 in C57BL/KsJ db/db...

Journal: :European journal of endocrinology 2008
K M Choi J S Lee E J Kim S H Baik H S Seo D S Choi D J Oh C G Park

OBJECTIVES Visfatin and lipocalin-2 are novel adipokines associated with insulin resistance (IR) and obesity-related metabolic disorders. We compared lipocalin-2 and visfatin concentrations between patients with coronary heart disease (CHD) and control subjects and evaluated their association with cardiovascular risk factors. METHODS We examined serum visfatin, lipocalin-2 levels, and cardiov...

Journal: :The Journal of biological chemistry 2005
Jun-ichi Hanai Tadanori Mammoto Pankaj Seth Kiyoshi Mori S Ananth Karumanchi Jonathan Barasch Vikas P Sukhatme

Lipocalin 2, an iron-siderophore-binding protein, converts embryonic kidney mesenchyme to epithelia. We found that lipocalin 2 could also convert 4T1-Ras-transformed mesenchymal tumor cells to an epithelial phenotype, increase E-cadherin expression, and suppress cell invasiveness in vitro and tumor growth and lung metastases in vivo. The Ras-MAPK pathway mediated the epithelial to mesenchymal t...

2010
Hong Wu Eric Santoni-Rugiu Elisabeth Ralfkiaer Bo T Porse Claus Moser Niels Høiby Niels Borregaard Jack B Cowland

BACKGROUND Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hi...

2013
Farzaneh Sharifipour Abbasali Zeraati Maryam Sahebari Mohammadreza Hatef Masih Naghibi Zahra Rezaieyazdi Mahmoud Mahmoudi Amir Abbas Azarian Zahra Mirfeizi Katayoun Samadi

OBJECTIVE(S) Lupus nephritis (LN) is the main cause of mortality and disability in systemic lupus erythematosus (SLE) patients. Therefore, utilizing a reliable and non-invasive method for serial measurements of renal function seems to be necessary. The aim of this study was to evaluate the role of urinary lipocalin-2 as a biomarker of renal involvement in SLE patients. MATERIALS AND METHODS F...

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