1) Fat or too plentiful diets (associated to obesity and increased abdominal fat bodies). Diagnosed in badly fed crocodiles, lizards and turtles (Maccolini 2010). 2) Reduced activity. Absence of exercise. Diagnosed in monitors and turtles (Stahl 2003). 3) Physiologic disorder. Lack of hibernation. Lack of reproduction. Diagnosed in tortoises and iguanas. 4) Chronic hyporexia and stress. It decr...

The effect of tricyclic antidepressants (TCA) on phospholipid bilayer structure and dynamics was studied to provide insight into the mechanism of TCA-induced intracellular accumulation of lipids (known as lipidosis). Specifically we asked if the lipid-TCA interaction was TCA or lipid specific and if such physical interactions could contribute to lipidosis. These interactions were probed in mult...

Ophthalmoplegic lipidosis is a recently recognised neurovisceral storage disease which is also described as 'a neurovisceral storage disease with vertical supranuclear opthalmoplegia" or as 'juvenile dystonic lipidosis.'23 The clinical presentation varies, but there appear to be 3 groups of patients: firstly, those who present in infancy with failure to thrive, jaundice, and hepatosplenomegaly;...

C HRONIC cholesterol feeding leads to the development of atherosclerosis in the chick."' 2 In all our previous studies, marked hypercholesterolemia and organ lipidosis were consistent concomitants of this cholesterol-induced atheromatosis.'Human atherosclerosis frequently occurs in people with presumably normal plasma and tissue cholesterol levels. Ostensibly cholesterol metabolism is not deran...

INTRODUCTION A lagille syndrome (ALGS) results from mutations in JAG1 and NOTCH2 in the Notch signaling pathway. These mutations clinically manifest in various ways, but ALGS is most commonly characterized by a paucity of bile ducts in the liver. ALGS often involves the kidney, which can be characterized by defects in the glomerular vasculature, podocytes, proximal tubules, and renal dysplasia....

Hepatic lipidosis, a hallmark lesion of lipid mobilization disorders in ruminants, was noted in four 3-year-old, pregnant bison (Bison bison) after periods of anorexia that progressed to recumbency and death. The affected bison were part of a herd at the National Animal Disease Center (NADC) that was used for brucellosis vaccine research. Microscopically, the liver contained swollen hepatocytes...

This study aimed to determine the relationship between ultrasonographic examination of hepatic lipidosis and obesity assessment parameters in cats different body conditions. For this purpose, 27 conditions which have not any systemic health problems were evaluated. Body condition score fat index examined by inspection palpation; subcutaneous adipose tissue thickness, hepatorenal grade ultrasono...

C HRONIC cholesterol feeding leads to the development of atherosclerosis in the chick."' 2 In all our previous studies, marked hypercholesterolemia and organ lipidosis were consistent concomitants of this cholesterol-induced atheromatosis.'Human atherosclerosis frequently occurs in people with presumably normal plasma and tissue cholesterol levels. Ostensibly cholesterol metabolism is not deran...