The investigation of the intermolecular interactions between platinum-based anticancer drugs and lipid bilayers is special relevance to unveil mechanisms involved in different steps mode action these drugs. We have simulated permeation cisplatin through a model membrane composed 1,2-dioleoyl-sn-glycero-3-phosphocholine lipids by means umbrella sampling classical molecular dynamics simulations. ...

barley (hordeum vulgare l.) is a model plant, as genetic and physiological studies are concerned. abiotic stresses such as drought adversely affect the growth of plants. the objective of this experiment was to identify the responsive genes to osmotic stress, using macroarray (covering 13050 genes). rna was extracted from 5 barley genotypes in stress as well as in normal conditions at 3 times of...

Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and su...

conclusions these outcomes support our theory that rapamycin increases oxidative stress in mcf-7 and mda mb-231 cells but also shows high levels of antioxidant effects, which probably limit the effects of the rapamycin on the same issue in the clinic. methods the mcf-7 and mda mb-231 cell lines were cultivated and treated with rapamycin for 72 hours. the viability of the cells was determined us...

• Tetrahydrocurcumin (THC) improves glucose and lipid metabolism disorders in nonalcoholic fatty liver disease (NAFLD) mice. THC regulates the expression of oxidoreductase genes lipid-metabolizing enzyme NAFLD increases antioxidant capacity inhibits deposition HepG2 cells by activating NRF2 signaling pathway. Nonalcoholic is most common metabolic world. In this study we investigated effect tetr...

Objective(s): This study aimed to investigate the glucose and lipid metabolism improving effect of the total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, and to study its mechanism of action.Materials and Methods: The db/db mice were divided into 5 groups: the normal group (NC), the diabetic group (DM), t...

Abstract Wheat is cultivated worldwide and the most widely distributed food crop. a staple crop in many countries. However, effects of various cultivation methods on efficacy wheat sprouts have not been determined. This study investigated obtained using standardized smart farm system (WS-S) to improve non-alcoholic fatty liver disease (NAFLD) molecular mechanism. significantly attenuated accumu...

Acinetobacter baumannii ATCC 19606 can grow without lipid A, the major component of lipooligosaccharide. However, we previously reported that depletion of LpxH (the fourth enzyme in the lipid A biosynthetic pathway) prevented growth of this strain due to toxic accumulation of lipid A pathway intermediates. Here, we explored whether a similar phenomenon occurred with depletion of LpxK, a kinase ...